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Identification of a calcium phosphoserine coordination network in an adhesive organo-apatitic bone cement system.
Acta Biomaterialia ( IF 9.7 ) Pub Date : 2020-01-13 , DOI: 10.1016/j.actbio.2020.01.007
Fioleda P Kesseli 1 , Caroline S Lauer 1 , Ian Baker 1 , Katherine A Mirica 1 , Douglas W Van Citters 1
Affiliation  

Calcium phosphate-based bone cements have been widely adopted in both orthopedic and dental applications. Phosphoserine (pSer), which has a natural role in biomineralization, has been identified to possess the functionality to react with calcium phosphate phases, such as tetracalcium phosphate (TTCP) and α-tricalcium phosphate (α-TCP), and form a uniquely adhesive cement. This study investigated the chemical composition and phase evolution of a heterogeneous calcium phosphate (56% TTCP and 15% α-TCP) and pSer cement system with respect to pH. The coordination network of calcium phosphoserine monohydrate was discovered as the predominant crystalline phase of this adhesive apatitic cement system. Furthermore, it was determined that pH has a significant effect on the reaction kinetics of the system, whereby a lower pH tends to accelerate the reaction rate and favor products with lower Ca/P ratios. These findings provide a better understanding of the reaction and products of this adhesive organo-ceramic cement, which can be compositionally tuned for broad applications in the orthopedic and dental spaces. STATEMENT OF SIGNIFICANCE: The application of self-setting calcium phosphate cements (CPCs) in hard tissue regeneration has been a topic of significant research since their introduction to the field 30 years ago. Traditional CPCs, however, are limited by their suboptimal mechanical properties due to their solely inorganic composition. Recently, it was discovered that monomeric phosphoserine (pSer) is capable of serving as a setting reagent for a subset of CPC systems, resulting in an adhesive organo-ceramic composite. Despite its adhesive functionality and biomedical potential, its reaction chemistry and product composition were not well characterized. The present study identifies a calcium phosphoserine coordination network as the primary crystalline phase of this apatitic cement system and further characterizes compositional tunability of the products with respect to pH.

中文翻译:

粘合剂有机-脂肪骨水泥体系中磷酸丝氨酸钙配位网络的鉴定。

磷酸钙基骨水泥已在整形外科和牙科应用中广泛采用。在生物矿化中具有天然作用的磷酸丝氨酸(pSer)已被确定具有与磷酸钙相反应的功能,如磷酸四钙(TTCP)和α-磷酸三钙(α-TCP),并形成独特的粘合剂水泥。这项研究调查了非均相磷酸钙(56%TTCP和15%α-TCP)和pSer水泥体系相对于pH的化学组成和相演变。发现磷酸钙丝氨酸钙一水合物的配位网络是该胶凝性胶凝水泥体系的主要结晶相。此外,已确定pH对系统的反应动力学有重大影响,因此,较低的pH值倾向于加快反应速度,并有利于Ca / P比较低的产物。这些发现使人们对这种有机陶瓷胶粘剂的反应和产物有了更好的了解,可以对其成分进行调整以在整形外科和牙科用空间中广泛应用。意义声明:自30年来,自固化磷酸钙水泥(CPC)在硬组织再生中的应用一直是一项重要的研究课题。但是,传统的CPC由于仅具有无机成分,因此受到次优机械性能的限制。最近,发现单体磷酸丝氨酸(pSer)能够用作CPC系统子集的固化剂,从而产生有机陶瓷粘合复合材料。尽管其具有粘合功能和生物医学潜力,但其反应化学和产物组成并未得到很好的表征。本研究确定了磷酸丝氨酸钙配位网络作为该胶凝水泥体系的主要结晶相,并进一步表征了产品相对于pH的组成可调性。
更新日期:2020-01-13
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