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Optical coherence tomography of the retina in schizophrenia: Inter-device agreement and relations with perceptual function
Schizophrenia Research ( IF 4.5 ) Pub Date : 2020-05-01 , DOI: 10.1016/j.schres.2019.10.046
Margaret Miller 1 , Vance Zemon 2 , Rachel Nolan-Kenney 3 , Laura J Balcer 4 , Donald C Goff 5 , Michelle Worthington 6 , Lisena Hasanaj 7 , Pamela D Butler 5
Affiliation  

BACKGROUND Optical coherence tomography (OCT) studies have demonstrated differences between people with schizophrenia and controls. Many questions remain including the agreement between scanners. The current study seeks to determine inter-device agreement of OCT data in schizophrenia compared to controls and to explore the relations between OCT and visual function measures. METHODS Participants in this pilot study were 12 individuals with schizophrenia spectrum disorders and 12 age- and sex-matched controls. Spectralis and Cirrus OCT machines were used to obtain retinal nerve fiber layer (RNFL) thickness and macular volume. Cirrus was used to obtain ganglion cell layer + inner plexiform layer (GCL + IPL) thickness. Visual function was assessed with low-contrast visual acuity and the King-Devick test of rapid number naming. RESULTS There was excellent relative agreement in OCT measurements between the two machines, but poor absolute agreement, for both patients and controls. On both machines, people with schizophrenia showed decreased macular volume but no difference in RNFL thickness compared to controls. No between-group difference in GCL + IPL thickness was found on Cirrus. Controls showed significant associations between King-Devick performance and RNFL thickness and macular volume, and between low-contrast visual acuity and GCL + IPL thickness. Patients did not show significant associations between OCT measurements and visual function. CONCLUSIONS Good relative agreement suggests that the offset between machines remains constant and should not affect comparisons between groups. Decreased macular volume in individuals with schizophrenia on both machines supports findings of prior studies and provides further evidence that similar results may be found irrespective of OCT device.

中文翻译:

精神分裂症视网膜的光学相干断层扫描:设备间的一致性和与知觉功能的关系

背景光学相干断层扫描 (OCT) 研究已经证明精神分裂症患者和对照组之间存在差异。许多问题仍然存在,包括扫描仪之间的协议。目前的研究旨在确定与对照组相比,精神分裂症患者 OCT 数据的设备间一致性,并探讨 OCT 与视觉功能测量之间的关系。方法 这项试点研究的参与者是 12 名精神分裂症谱系障碍患者和 12 名年龄和性别匹配的对照组。Spectralis 和 Cirrus OCT 机器用于获得视网膜神经纤维层 (RNFL) 厚度和黄斑体积。卷云用于获得神经节细胞层 + 内丛状层 (GCL + IPL) 厚度。视觉功能通过低对比度视力和快速数字命名的 King-Devick 测试进行评估。结果 两台机器之间的 OCT 测量值具有极好的相对一致性,但对于患者和对照而言,绝对一致性较差。在两台机器上,与对照组相比,精神分裂症患者的黄斑体积减少,但 RNFL 厚度没有差异。在 Cirrus 上没有发现 GCL + IPL 厚度的组间差异。对照显示 King-Devick 性能与 RNFL 厚度和黄斑体积之间以及低对比度视力与 GCL + IPL 厚度之间存在显着关联。患者没有表现出 OCT 测量和视觉功能之间的显着关联。结论 良好的相对一致性表明机器之间的偏移保持不变,不应影响组之间的比较。
更新日期:2020-05-01
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