Usually health risk related to food contaminants is assessed based on consumption data collected on a few days. Consequently, this approach considers neither the evolution of exposures over time nor the potential accumulation of the substance. The aim of the present study was to develop a method to assess lifetime dietary risk due to cadmium exposure. Three methods were compared, respectively based on age, dietary pattern and sociodemographic characteristics. Additionally, exposure trajectories were converted into cadmium body burden trajectories using a PBTK-TD model ultimately predicting the occurrence of renal effects. It was shown that dietary exposures to cadmium, as well as exceedances of health based guidance values, greatly vary with age and individual profiles. The developed methods allowed identifying parameters affecting dietary exposure to cadmium and distinguishing at-risk subpopulations. Furthermore, this study demonstrated that it is necessary to consider individual changes through life and kinetic of the substance to assess risk properly.

中文翻译：

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一种评估终生饮食风险的方法：镉暴露的例子。

通常，根据几天收集的消费数据评估与食品污染物有关的健康风险。因此，该方法既不考虑暴露随时间的演变，也不考虑物质的潜在积累。本研究的目的是开发一种评估因镉暴露而终生饮食风险的方法。比较了三种方法，分别基于年龄，饮食模式和社会人口统计学特征。此外，使用PBTK-TD模型将暴露轨迹转换为镉人体负担轨迹，从而最终预测肾功能的发生。研究表明，饮食中镉的暴露量以及超过健康指导值的情况，随年龄和个人情况的不同而有很大差异。所开发的方法可以识别影响饮食中镉暴露的参数，并区分高危人群。此外，这项研究表明，有必要考虑物质的生命和动力学的个体变化，以正确评估风险。