BACKGROUND Although increased height is associated with a risk of atrial fibrillation (AF), the mechanism is not well understood. We aimed to explore whether this association varies with metabolic conditions. METHODS AND RESULTS We used the database from the 14-year Korea National Health Insurance Service-National Sample Cohort. The data of 368,206 adults older than 20 years who received a health check-up were analyzed to explore the association of height and AF risk. Cox proportional hazards regression models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) for associations of height with the risk of AF. During the median follow up duration of 8.46 years, 2641 (0.72%) patients were diagnosed with AF at 3,070,724 person-years. Overall, greater height was significantly associated with AF risk (HR per 5 cm, 1.22; 95% CI, 1.03-1.05). The association did not vary with age, sex, obesity, hypertension, and diabetes. CONCLUSION Metabolic conditions do not affect the higher risk of AF in tall people.

中文翻译：

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身高与一个大型亚洲人群的房颤相关。

背景技术尽管身高增加与心房颤动（AF）的风险有关，但其机理尚不十分清楚。我们旨在探讨这种关联是否随代谢状况而变化。方法和结果我们使用了14年的韩国国民健康保险服务-国家样本队列的数据库。分析了接受健康检查的368206名20岁以上成年人的数据，以探讨身高与房颤风险之间的关系。使用Cox比例风险回归模型计算身高与房颤风险的风险比（HRs）和95％置信区间（CIs）。在8.46年的中位随访期间，有2,641（0.72％）名患者被诊断为AF，患病率为3,070,724人年。总体而言，身高升高与房颤风险显着相关（每5厘米HR，1.22； 95％CI，1.03-1.05）。年龄，性别，肥胖，高血压和糖尿病的相关性没有变化。结论代谢状况不会影响高个子人群房颤的高风险。