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Visible light in photodermatology.
Photochemical & Photobiological Sciences ( IF 3.1 ) Pub Date : 2020-01-10 , DOI: 10.1039/c9pp00425d
Shanthi Narla 1 , Indermeet Kohli 1 , Iltefat H Hamzavi 1 , Henry W Lim 1
Affiliation  

Until recently, visible light (VL) had been regarded to be without significant photobiologic effect on the skin. Updated research suggests that this is not the case and the measurable effect of visible light on the skin is being documented in all skin types. Recent studies have demonstrated that in dark-skinned individuals, visible light can induce more intense and longer lasting pigmentation of the skin compared to UVA1. This effect was potentiated when VL was combined with a small percentage of ultraviolet A1 radiation (UVA1). Further, the combination of VL + UVA1 was also able to induce erythema in light-skinned individuals, a novel finding since the erythemogenic spectrum of sunlight had primarily been attributed to ultraviolet B (UVB) and short wavelength UVA (320-340 nm). Based on these findings, VL and UVA1 may also potentially play a role in conditions aggravated by sun exposure such as phototoxicity in light-skinned patients and post-inflammatory hyperpigmentation and melasma, especially in dark-skinned individuals. Currently available organic (chemical) UV filters are not sufficient to protect the skin from the effect of VL. VL is emerging as a key player in photodermatology and additional research is needed on the cutaneous effects of VL, as well as the development of filters and other means of photoprotection against the harmful effects of the VL spectrum. The aim of this manuscript is to review the literature on the cutaneous effects of VL as well as to highlight areas of dermatology where VL may play an important role.

中文翻译:

光皮肤病学中的可见光。

直到最近,可见光(VL)一直被认为对皮肤没有明显的光生物学作用。最新的研究表明事实并非如此,可见光对皮肤的可测量效果已在所有皮肤类型中得到了证明。最近的研究表明,与UVA1相比,在深色皮肤的人中,可见光可以诱导更强烈和更持久的皮肤色素沉着。当VL与少量紫外线A1(UVA1)结合使用时,这种效果会增强。此外,VL + UVA1的组合还能够在浅肤色的个体中诱发红斑,这是一个新发现,因为阳光的红斑生成光谱主要归因于紫外线B(UVB)和短波长UVA(320-340 nm)。根据这些发现,VL和UVA1可能在因阳光暴晒而加剧的疾病中发挥作用,例如浅肤色患者的光毒性和炎症后色素沉着和黄褐斑,尤其是深色皮肤患者。当前可用的有机(化学)UV过滤器不足以保护皮肤免受VL的影响。VL逐渐成为光皮肤病学中的关键角色,需要进一步研究VL的皮肤作用,以及开发滤光片和其他针对VL光谱的有害作用的光防护方法。该手稿的目的是回顾有关VL的皮肤作用的文献,并突出显示VL可能起重要作用的皮肤病学领域。
更新日期:2020-02-13
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