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Reisolation and Configurational Reinvestigation of Cottoquinazolines E-G from an Arthropod-Derived Strain of the Fungus Neosartorya fischeri.
Journal of Natural Products ( IF 5.1 ) Pub Date : 2020-01-10 , DOI: 10.1021/acs.jnatprod.9b01000 Shuang Lin 1 , Huimin Yu 2 , Beiye Yang 1 , Fengli Li 1 , Xia Chen 1 , Huaqiang Li 1 , Sitian Zhang 1 , Jianping Wang 1 , Youcai Hu 3 , Zhengxi Hu 1 , Yonghui Zhang 1
Journal of Natural Products ( IF 5.1 ) Pub Date : 2020-01-10 , DOI: 10.1021/acs.jnatprod.9b01000 Shuang Lin 1 , Huimin Yu 2 , Beiye Yang 1 , Fengli Li 1 , Xia Chen 1 , Huaqiang Li 1 , Sitian Zhang 1 , Jianping Wang 1 , Youcai Hu 3 , Zhengxi Hu 1 , Yonghui Zhang 1
Affiliation
The reported fumiquinazoline-related alkaloids cottoquinazolines E-G (1-3) were reisolated from solid cultures of the fungus Neosartorya fischeri, which was isolated from the medicinal arthropod Cryptotympana atrata. The unresolved issues regarding the absolute configurations (for cottoquinazolines E and F) prompted a reinvestigation of the configurations for all three compounds, as enabled by extensive spectroscopic methods, comparisons of experimental electronic circular dichroism data, and X-ray crystallography. In addition, cottoquinazoline F (2) showed significant antibacterial activity against ESBL-producing Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterococcus faecalis with MIC values of 8, 32, 32, and 16 μg/mL, respectively.
中文翻译:
节肢动物衍生菌株费氏新藻类的库托喹唑啉EG的分离和构型再研究。
从真菌节肢动物Cryptotympana atrata分离出的真菌Neosartorya fischeri的固体培养物中,重新分离出了与氟米喹唑啉相关的生物碱库托喹唑啉EG(1-3)。关于绝对构型(对甲喹啉E和F)的未解决问题促使人们对这三种化合物的构型进行了重新研究,这可以通过广泛的光谱方法,实验性电子圆二色性数据比较和X射线晶体学来实现。此外,库托喹唑啉F(2)对产生ESBL的大肠杆菌,鲍曼不动杆菌,铜绿假单胞菌和粪肠球菌显示出显着的抗菌活性,MIC值分别为8、32、32和16μg/ mL。
更新日期:2020-01-10
中文翻译:
节肢动物衍生菌株费氏新藻类的库托喹唑啉EG的分离和构型再研究。
从真菌节肢动物Cryptotympana atrata分离出的真菌Neosartorya fischeri的固体培养物中,重新分离出了与氟米喹唑啉相关的生物碱库托喹唑啉EG(1-3)。关于绝对构型(对甲喹啉E和F)的未解决问题促使人们对这三种化合物的构型进行了重新研究,这可以通过广泛的光谱方法,实验性电子圆二色性数据比较和X射线晶体学来实现。此外,库托喹唑啉F(2)对产生ESBL的大肠杆菌,鲍曼不动杆菌,铜绿假单胞菌和粪肠球菌显示出显着的抗菌活性,MIC值分别为8、32、32和16μg/ mL。