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Smart Flexible Electronics‐Integrated Wound Dressing for Real‐Time Monitoring and On‐Demand Treatment of Infected Wounds
Advanced Science ( IF 15.1 ) Pub Date : 2020-01-10 , DOI: 10.1002/advs.201902673
Qian Pang 1 , Dong Lou 1 , Shijian Li 2 , Guangming Wang 3 , Bianbian Qiao 1 , Shurong Dong 3 , Lie Ma 1 , Changyou Gao 1 , Zhaohui Wu 2
Affiliation  

As the most frequent wound complication, infection has become a major clinical challenge in wound management. To overcome the “Black Box” status of the wound‐healing process, next‐generation wound dressings with the abilities of real‐time monitoring, diagnosis during early stages, and on‐demand therapy has attracted considerable attention. Here, by combining the emerging development of bioelectronics, a smart flexible electronics‐integrated wound dressing with a double‐layer structure, the upper layer of which is polydimethylsiloxane‐encapsulated flexible electronics integrated with a temperature sensor and ultraviolet (UV) light‐emitting diodes, and the lower layer of which is a UV‐responsive antibacterial hydrogel, is designed. This dressing is expected to provide early infection diagnosis via real‐time wound‐temperature monitoring by the integrated sensor and on‐demand infection treatment by the release of antibiotics from the hydrogel by in situ UV irradiation. The integrated system possesses good flexibility, excellent compatibility, and high monitoring sensitivity and durability. Animal experiment results demonstrate that the integrated system is capable of monitoring wound status in real time, detecting bacterial infection and providing effective treatment on the basis of need. This proof‐of‐concept research holds great promise in developing new strategies to significantly improve wound management and other pathological diagnoses and treatments.

中文翻译:

智能柔性电子集成伤口敷料,可实时监测和按需治疗感染伤口

作为最常见的伤口并发症,感染已成为伤口处理中的主要临床挑战。为了克服伤口愈合过程中的“黑匣子”状态,具有实时监测,早期诊断和按需治疗能力的新一代伤口敷料引起了广泛关注。在这里,通过结合生物电子学的新兴发展,一种具有双层结构的智能柔性电子集成伤口敷料,其上层是与温度传感器和紫外线(UV)发光二极管集成在一起的聚二甲基硅氧烷封装的柔性电子产品设计了其下层是紫外线响应抗菌水凝胶。预计该敷料将通过集成传感器实时伤口温度监测和通过原位紫外线照射从水凝胶中释放抗生素来按需治疗感染,从而提供早期感染诊断。该集成系统具有良好的灵活性,出色的兼容性以及较高的监视灵敏度和耐用性。动物实验结果表明,该集成系统能够实时监控伤口状态,检测细菌感染并根据需要提供有效的治疗。这项概念验证研究在开发新策略以显着改善伤口管理和其他病理学诊断和治疗方法方面具有广阔的前景。该集成系统具有良好的灵活性,出色的兼容性以及较高的监视灵敏度和耐用性。动物实验结果表明,该集成系统能够实时监控伤口状态,检测细菌感染并根据需要提供有效的治疗。这项概念验证研究在开发新策略以显着改善伤口管理和其他病理学诊断和治疗方法方面具有广阔的前景。该集成系统具有良好的灵活性,出色的兼容性以及较高的监视灵敏度和耐用性。动物实验结果表明,该集成系统能够实时监控伤口状态,检测细菌感染并根据需要提供有效的治疗。这项概念验证研究在开发新策略以显着改善伤口管理和其他病理学诊断和治疗方法方面具有广阔的前景。
更新日期:2020-01-11
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