Metal-organic frameworks (MOFs) formed by coordination between metal ions or clusters and organic bridging ligands possess great potential for biomedicine applications, given their high biocompatibility and biodegradability. Compared with the traditional three-dimensional (3D) MOFs, two-dimensional (2D) MOFs with sheet-like morphologies exhibit unique properties. In this study, a nanoscale 2D leaf-shaped MOF (NZIF-L) was synthesized via coordination self-assembly between 2-methylimidazole (Hmim) and Zn2+ with subsequent morphology and size control. The fabricated NZIF-L is cytocompatible and can be quickly endocytosed, which makes it an excellent cargo carrier. Subsequent to loading with either doxorubicin (DOX) or 4,4'-(1,2-diphenylvinyl)-1,2-di-(phenylcarboxylic acid) (TCPE), the respectively obtained DOX@NZIF-L and TCPE@NZIF-L showed promise for killing and imaging cancer cells.

中文翻译：

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用于高效药物输送和生物成像的金属有机薄板。

由于金属离子或簇与有机桥联配体之间的配合而形成的金属有机骨架（MOF）具有高度的生物相容性和生物降解性，因此在生物医学应用中具有巨大的潜力。与传统的三维（3D）MOF相比，具有片状形态的二维（2D）MOF具有独特的性能。在这项研究中，通过2-甲基咪唑（Hmim）和Zn2 +之间的配位自组装合成了纳米级二维叶状MOF（NZIF-L），随后进行了形态和尺寸控制。制成的NZIF-L具有细胞相容性，可以快速内吞，使其成为出色的货物载体。加入阿霉素（DOX）或4,4'-（1,2-二苯基乙烯基）-1,2-二-（苯基羧酸）（TCPE）后，