Objectives

To systematically review the diagnostic accuracy of brain natriuretic peptide (BNP) and amino-terminal pro-B-type natriuretic peptide (NT-proBNP) in bronchopulmonary dysplasia (BPD) and BPD-pulmonary hypertension (PH).

Study design

PubMed, Embase, the Web of Science, and the Cochrane Library were searched in March 2019. We included studies that evaluated BNP or NT-proBNP in preterm neonates as a marker for predicting BPD, BPD or death, and BPD-PH.

Results

Nine studies evaluating NT-proBNP/BNP were included. The quality of evidence was low, using GRADE criteria. The diagnostic accuracy of NT-proBNP and BNP for diagnosing BPD-PH showed high sensitivity and specificity in infants with BPD. Lower sensitivities and specificities of NT-proBNP and BNP were reported for predicting BPD, BPD or death, compared with that for BPD-PH.

Conclusions

Low quality evidence suggests that NT-proBNP and BNP have adequate diagnostic accuracy for diagnosing and monitoring BPD-PH and may be used to triage patients to receive an echocardiogram.

中文翻译：

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支气管肺发育不良中的利钠肽：系统评价

目标

系统评价脑利钠肽（BNP）和氨基末端B型利钠肽前体（NT-proBNP）在支气管肺发育不良（BPD）和BPD-肺动脉高压（PH）中的诊断准确性。

学习规划

PubMed、Embase、Web of Science 和 Cochrane 图书馆于 2019 年 3 月进行了检索。我们纳入了评估早产儿 BNP 或 NT-proBNP 作为预测 BPD、BPD 或死亡和 BPD-PH 的标志物的研究。

结果

纳入评估 NT-proBNP/BNP 的九项研究。使用 GRADE 标准，证据质量低。NT-proBNP 和 BNP 对 BPD-PH 诊断的准确性在 BPD 婴儿中显示出较高的敏感性和特异性。据报道，与 BPD-PH 相比，NT-proBNP 和 BNP 预测 BPD、BPD 或死亡的敏感性和特异性较低。

结论

低质量证据表明 NT-proBNP 和 BNP 在诊断和监测 BPD-PH 方面具有足够的诊断准确性，可用于对患者进行分类以接受超声心动图。