Follicular thyroid carcinoma (FTC) is a common endocrine malignancy with highly aggressive features. In this study, next-generation sequencing technology was used to identify aberrant expression of sialyltransferase (ST) family members in FTC. Aberrant high expression of alpha-2,6-sialyltransferase 2 (ST6GAL2) was demonstrated to promote tumorigenesis of FTC in vitro and in vivo. Furthermore, ST6GAL2 promoted tumorigenesis by inactivating the Hippo signaling pathway. Resveratrol is a native compound extracted from Vitis species, and many studies have confirmed its protective cardiovascular and antineoplastic effects. Here we found that resveratrol can inhibit the tumorigenesis of FTC by suppressing the expression of ST6GAL2, further activating the Hippo pathway. In summary, this study revealed the role of the ST6GAL2-Hippo signaling pathway in FTC tumorigenesis and indicated that resveratrol, a commonly found antineoplastic compound, could inhibit tumorigenesis of FTC by regulating the abovementioned pathways.

滤泡性甲状腺癌（FTC）是一种常见的内分泌恶性肿瘤，具有高度侵袭性。在这项研究中，下一代测序技术用于鉴定FTC中唾液酸转移酶（ST）家族成员的异常表达。异常高表达的α-2,6-唾液酸转移酶2（ST6GAL2）被证明可以促进FTC在体外和体内的肿瘤发生。此外，ST6GAL2通过灭活Hippo信号通路来促进肿瘤发生。白藜芦醇是从葡萄中提取的天然化合物物种，许多研究已证实其具有保护心血管和抗肿瘤作用。在这里，我们发现白藜芦醇可以通过抑制ST6GAL2的表达来抑制FTC的肿瘤发生，从而进一步激活Hippo途径。总之，该研究揭示了ST6GAL2-Hippo信号传导途径在FTC肿瘤发生中的作用，并表明白藜芦醇是一种常见的抗肿瘤化合物，可以通过调节上述途径来抑制FTC的肿瘤发生。