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Effective PEGylation Method to Improve Biocompatibility of Graphene Derivatives
European Polymer Journal ( IF 6 ) Pub Date : 2020-02-01 , DOI: 10.1016/j.eurpolymj.2020.109504
Erhan Demirel , Ezgi Karaca , Yasemin Yuksel Durmaz

Abstract The research on the use of graphene (G) in the biological applications has increased exponentially with emerging concerns regarding its biosafety and potential cytotoxicity. The modification of the surface with biocompatible polymers is a promising approach where poly(ethylene glycol) (PEG) have been extensively used. However, increasing water solubility may not be enough to make G biocompatible since it has different cytotoxicity mechanisms like absorbing cell nutrition on its wide surface area and creating reactive oxygen species through its functional groups. A PEGylation method that uses surface area of graphene oxide (GO) by taking advantage of its solubility in aqueous medium and simultaneously producing reduced GO (rGO) to eliminate the cytotoxicity that comes from functional groups might be a solution to improve biocompatibility and solubility of rGO which is an optimum graphene derivative for biological applications. To have surface PEGylated rGO instead of having edge PEGylated GO; P(PEGMA-co-MMA-co-PMA) copolymers were synthesized and coated on GO via π-π interactions through multiple pyrene units in the copolymer. Healed conjugated surface of rGO was used as an advantage to increase the efficiency of PEGylation by in-situ reduction of GO to rGO in the presence of copolymer to obtain biocompatible, water dispersible, highly PEGylated rGO.

中文翻译:

提高石墨烯衍生物生物相容性的有效聚乙二醇化方法

摘要 石墨烯 (G) 在生物应用中的使用研究呈指数级增长,其生物安全性和潜在的细胞毒性引起了人们的关注。用生物相容性聚合物对表面进行改性是一种很有前景的方法,其中聚乙二醇 (PEG) 已被广泛使用。然而,增加水溶性可能不足以使 G 具有生物相容性,因为它具有不同的细胞毒性机制,例如在其广泛的表面积上吸收细胞营养并通过其官能团产生活性氧。一种利用氧化石墨烯 (GO) 表面积的聚乙二醇化方法,利用其在水性介质中的溶解性,同时产生还原的 GO (rGO) 以消除来自官能团的细胞毒性,这可能是提高 rGO 的生物相容性和溶解性的解决方案它是生物应用的最佳石墨烯衍生物。具有表面聚乙二醇化的 rGO,而不是具有边缘聚乙二醇化的 GO;P(PEGMA-co-MMA-co-PMA)共聚物被合成并通过共聚物中的多个芘单元的π-π相互作用被包覆在GO上。通过在共聚物存在下将 GO 原位还原为 rGO,将 rGO 的修复共轭表面用作提高聚乙二醇化效率的优势,以获得生物相容性、水分散性、高度聚乙二醇化的 rGO。
更新日期:2020-02-01
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