The layered cladding sea cucumber-like covalent organic framework incorporated magnetic carbon nanotube (CTC-COF@MCNT) was prepared by photochemical synthesis. The magnetic composite was fabricated by filling magnetic nanoparticles inside carbon nanotubes and depositing covalent organic framework shell on the outside. The composites exhibited large specific surface area, high stability and adsorption capacity for heterocyclic aromatic amines. Therefore, CTC-COF@MCNT was applied as adsorbent for magnetic solid-phase extraction to enrich the heterocyclic aromatic amines from complex food samples prior to the determination by ultra-high performance liquid chromatography-tandem mass spectrometry. The adsorption mechanism between CTC-COF@MCNT and heterocyclic aromatic amines was discussed and verified by Gaussian simulation. The effect of adsorbent amount, extraction conditions and desorption conditions on the efficiency of pretreatment were optimized. The established method revealed wide linear range and high sensitivity with the LODs ranging from 0.0058 to 0.025 ng/g. Furthermore, the developed method was successfully applied to determine heterocyclic aromatic amines in fried chicken and roast beef. Satisfactory recoveries were obtained, which demonstrated the promising potential of CTC-COF@MCNT as good adsorbent for pretreatment of trace analytes.

通过光化学合成法制备了层状包覆海参状共价有机骨架并入了磁性碳纳米管（CTC-COF @ MCNT）。通过将磁性纳米粒子填充到碳纳米管内部，并在外部沉积共价有机骨架壳，可以制成磁性复合材料。该复合材料表现出大的比表面积，高稳定性和对杂环芳族胺的吸附能力。因此，在通过超高效液相色谱-串联质谱法测定之前，将CTC-COF @ MCNT用作吸附剂用于磁性固相萃取，以从复杂食品中富集杂环芳香胺。讨论并通过高斯模拟验证了CTC-COF @ MCNT与杂环芳香胺之间的吸附机理。优化了吸附剂用量，萃取条件和解吸条件对预处理效率的影响。建立的方法显示出宽线性范围和高灵敏度，LOD为0.0058至0.025 ng / g。此外，该方法成功地用于测定炸鸡和烤牛肉中的杂环芳香胺。回收率令人满意，证明了CTC-COF @ MCNT作为用于痕量分析物预处理的良好吸附剂的潜力很大。该方法成功地用于测定炸鸡和烤牛肉中的杂环芳香胺。回收率令人满意，证明了CTC-COF @ MCNT作为用于痕量分析物预处理的良好吸附剂的潜力很大。该方法成功地用于测定炸鸡和烤牛肉中的杂环芳香胺。回收率令人满意，证明了CTC-COF @ MCNT作为用于痕量分析物预处理的良好吸附剂的潜力很大。