Maltobionic acid is known to have an inhibitory effect on the differentiation of osteoclasts, and it has also been reported in an intervention trial that ingestion of corn syrup solids containing maltobionic acid maintained and increased the bone density of postmenopausal women. However, there is no information on whether maltobionic acid improves bone metabolism in humans. Therefore, we evaluated the influence of corn syrup solids containing maltobionic acid (maltobionic acid calcium salt) on bone resorption markers in healthy Japanese women. Forty‐one individuals were selected from 68 participants and assigned to two groups: 21 individuals in the test food antecedent group and 20 individuals in the placebo food antecedent group; individuals in the first group ingested 4 g of corn syrup solids containing maltobionic acid, and subjects in the second group ingested 4 g of placebo (hydrous crystalline maltose and calcium carbonate) for 4 weeks. Bone resorption marker levels (DPD and u‐NTx) were evaluated by urinalysis. Forty subjects completed the study, and no adverse events related to the test food were observed. Fourteen subjects were excluded prior to the efficacy analysis because of conflict with the control criteria; the remaining 33 subjects were analyzed. Consumption of corn syrup solids containing maltobionic acid was maintained; DPD and u‐NTx values were improved (p < .05). These results indicate that corn syrup solids containing maltobionic acid might contribute to suppress bone resorption and improve bone metabolism in postmenstrual women. (UMIN‐CTR ID: UMIN000034257; Foundation: San‐ei Sucrochemical Co., Ltd.).

中文翻译：

---

含麦芽糖酸（麦芽糖酸钙盐）的玉米糖浆固体对健康日本成年女性骨吸收的影响：一项随机双盲安慰剂对照交叉研究

已知麦芽糖酸对破骨细胞的分化具有抑制作用，并且在一项干预试验中也有报道称，摄入含有麦芽糖酸的玉米糖浆固体可以维持并增加绝经后妇女的骨密度。但是，没有关于麦芽糖酸是否能改善人体骨骼代谢的信息。因此，我们评估了含有麦芽糖酸（麦芽糖酸钙盐）的玉米糖浆固体对健康日本女性骨吸收指标的影响。从68名参与者中选择了41个人，并分为两组：测试食品前身组中的21个人和安慰剂食品前身组中的20个人。第一组中的人摄入了4克含有麦芽糖酸的玉米糖浆固体，第二组受试者则服用4克安慰剂（含水结晶麦芽糖和碳酸钙），持续4周。通过尿液分析评估骨吸收标记物水平（DPD和u‐NTx）。四十名受试者完成了研究，未观察到与试验食品相关的不良事件。由于与对照标准相抵触，在进行功效分析之前排除了14名受试者。其余33位受试者进行了分析。维持含有麦芽糖酸的玉米糖浆固体的消费；DPD和u‐NTx值得到改善（由于与对照标准相抵触，在功效分析之前排除了十四名受试者。其余33位受试者进行了分析。维持含有麦芽糖酸的玉米糖浆固体的消费；DPD和u‐NTx值得到改善（由于与对照标准相抵触，在进行功效分析之前排除了14名受试者。其余33位受试者进行了分析。维持含有麦芽糖酸的玉米糖浆固体的消费；DPD和u‐NTx值得到改善（p  <.05）。这些结果表明，含有麦芽糖酸的玉米糖浆固体可能有助于抑制月经后妇女的骨吸收并改善骨代谢。（UMIN-CTR ID：UMIN000034257；基金会：San-ei Sucrochemical Co.，Ltd.）。