Model‐Based Nanoengineered Pharmacokinetics of Iron‐Doped Copper Oxide for Nanomedicine Applications,Angewandte Chemie International Edition

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Model‐Based Nanoengineered Pharmacokinetics of Iron‐Doped Copper Oxide for Nanomedicine Applications
Angewandte Chemie International Edition ( IF 16.6 ) Pub Date : 2020-01-09 , DOI: 10.1002/anie.201916183
Hendrik Naatz _{1,

2} , Bella B. Manshian _{3,

4} , Carla Rios Luci _{3,

4} , Vasiliki Tsikourkitoudi ₅ , Yiannis Deligiannakis ₅ , Johannes Birkenstock ₆ , Suman Pokhrel _{1,

2} , Lutz Mädler _{1,

2} , Stefaan J. Soenen _{3,

4}

Affiliation

The controlled dissolution kinetics of iron‐doped copper oxide nanoparticles are applied in targeted nanomedicine. In their Research Article (DOI: 10.1002/anie.201912312), L. Mädler, S. J. Soenen et al. present a model‐based approach for adjusting the dissolution kinetics and intracellular release of copper that opens a therapeutic window for cancer treatment. Copper homeostasis regulates elevated copper levels for the slow release in peripheral cells but is insufficient for the fast release in cancer cells.

中文翻译：

纳米铁应用的基于模型的铁掺杂氧化铜的纳米工程药物动力学。

掺杂铁的氧化铜纳米粒子的受控溶出动力学应用于目标纳米药物中。L.Mädler，S.J.Soenen等人在其研究文章（DOI：10.1002 / anie.201912312）中提出了一种基于模型的方法来调节铜的溶解动力学和细胞内释放，为癌症治疗打开了治疗之窗。铜稳态调节了铜水平的升高，以使外周细胞缓慢释放，但不足以使癌细胞快速释放。

更新日期：2020-01-10

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