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Patient-derived xenograft models-the future of personalised cancer treatment.
British Journal of Cancer ( IF 8.8 ) Pub Date : 2020-01-10 , DOI: 10.1038/s41416-019-0678-0
Jenna Bhimani 1 , Katie Ball 1 , Justin Stebbing 1, 2
Affiliation  

For many tumours there is a lack of randomised data from which we can guide systemic treatments. Although gene expression profiling along with proteomics has led to advances in diagnosis, classification and prognosis, our ability to target many cancers has been further limited due to a lack of therapeutic options. The use of patient-derived xenograft (PDX) models in the setting of a rare malignancy is discussed here by Kamili et al, with the successful establishment of new model systems.

中文翻译:

患者来源的异种移植模型-个性化癌症治疗的未来。

对于许多肿瘤,我们缺乏随机数据来指导全身治疗。尽管基因表达谱和蛋白质组学已导致诊断,分类和预后方面的进步,但由于缺乏治疗选择,我们针对许多癌症的能力受到了进一步限制。Kamili等人在这里讨论了在罕见的恶性肿瘤中使用患者衍生的异种移植(PDX)模型,并成功建立了新的模型系统。
更新日期:2020-01-10
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