Insulin-like growth factor (IGF) binding protein 2 (IGFBP2) was discovered and identified as an IGF system regulator, controlling the distribution, function, and activity of IGFs in the pericellular space. IGFBP2 is a developmentally regulated gene that is highly expressed in embryonic and fetal tissues and markedly decreases after birth. Studies over the last decades have shown that in solid tumors, IGFBP2 is upregulated and promotes several key oncogenic processes, such as epithelial-to-mesenchymal transition, cellular migration, invasion, angiogenesis, stemness, transcriptional activation, and epigenetic programming via signaling that is often independent of IGFs. Growing evidence indicates that aberrant expression of IGFBP2 in cancer acts as a hub of an oncogenic network, integrating multiple cancer signaling pathways and serving as a potential therapeutic target for cancer treatment.

中文翻译：

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IGFBP2：发育和致癌信号网络的综合枢纽。

胰岛素样生长因子 (IGF) 结合蛋白 2 (IGFBP2) 被发现并被鉴定为 IGF 系统调节剂，可控制 IGF 在细胞周围空间的分布、功能和活性。IGFBP2 是一种发育调控基因，在胚胎和胎儿组织中高度表达，出生后显着降低。过去几十年的研究表明，在实体瘤中，IGFBP2 被上调并通过信号传导促进几个关键的致癌过程，例如上皮-间质转化、细胞迁移、侵袭、血管生成、干性、转录激活和表观遗传编程。通常独立于 IGF。越来越多的证据表明，癌症中 IGFBP2 的异常表达是致癌网络的中枢，