当前位置: X-MOL 学术Res. Chem. Intermed. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Design, synthesis and exploration of in silico α-amylase and α-glucosidase binding studies of pyrrolidine-appended quinoline-constrained compounds
Research on Chemical Intermediates ( IF 3.3 ) Pub Date : 2020-01-09 , DOI: 10.1007/s11164-019-04068-9
P. Hemanth Kumar , L. Jyothish Kumar , G. Pavithrra , R. Rajasekaran , V. Vijayakumar , Rohith Karan , S. Sarveswari

A series of new pyrrolidine-appended phenoxy-substituted quinoline derivatives were synthesized using 2-chloro-3-formyl quinoline. Initially, the second position of 2-chloro-3-formyl quinoline was successfully converted into various substituted phenoxy-substituted quinolines using various substituted phenols; then, its aldehyde function was reduced to its corresponding alcohols which is in turn converted into its corresponding pyrrolidine-appended phenoxy-substituted quinolines by treating it with 1-(2-chloroacetyl)pyrrolidine-2-carbonitrile. All these newly synthesized compounds were subjected to the in silico studies with the α-amylase and α-glucosidase enzymes to predict the binding affinity.



中文翻译:

吡咯烷附加喹啉约束化合物的计算机α-淀粉酶和α-葡萄糖苷酶结合研究的设计,合成和探索

使用2-氯-3-甲酰基喹啉合成了一系列新的吡咯烷附加的苯氧基取代的喹啉衍生物。最初,使用各种取代的苯酚将2-氯-3-甲酰基喹啉的第二个位置成功转化为各种取代的苯氧基取代的喹啉。然后,将其醛官能团还原成相应的醇,再用1-(2-氯乙酰基)吡咯烷-2-腈处理,将其转化为相应的吡咯烷附加的苯氧基取代的喹啉。所有这些新合成的化合物均使用α-淀粉酶和α-葡萄糖苷酶进行计算机模拟研究,以预测结合亲和力。

更新日期:2020-01-09
down
wechat
bug