The aim was to compare the antiobesity efficacy of different concentrations of a phenolic-rich water extract from purple maize pericarp (PPE) in a murine model of obesity for 12 weeks. Forty C57BL/6 mice (n=10/group) were randomized: standard diet (SD), high-fat diet (HFD), HFD+200 mg PPE/kg (200 PPE) and HFD+500 mg PPE/kg (500 PPE). PPE contained mainly ferulic acid, anthocyanins and other phenolics (total phenolics: 448.5 μg/mg dry weight, DW). Body weight (−27.9%), blood glucose (−26.5%) and blood triglycerides (−22.1%) were most attenuated (P<.05) in 500 PPE group compared to HFD group. Also, 500 PPE group had reduced (P<.05) plasma levels of TNF-α, MCP-1, resistin and leptin compared to HFD group. Fatty liver disease scores were highest for HFD (8.4), followed by 200 PPE (6.1), 500 PPE (2.7) and SD (0.4) groups. Relative adipose tissue was lower (P<.05) in 200 PPE (7.6%), 500 PPE (8.0%) and SD (0.8%) compared to HFD (12.1%) group. In 500 PPE group, compared to HFD group, important genes were modulated related to adipogenesis (Mmp3, fold-change [FC]=7.4), inflammation (Nfkb1, FC=−1.8) and glucose metabolism (Slc2a4, FC=23.6) in adipose tissue. In liver, 500 PPE group showed modulation of genes related to gluconeogenesis (Pck1, FC=−2.9), lipogenesis (Fasn, FC=−2.4) and β-oxidation (Cpt1b, FC=3.1). Maize rich in ferulic acid and anthocyanins prevented obesity through the modulation of TLR and AMPK signaling pathways reducing adipogenesis and adipose inflammation, and promoting energy expenditure.

目的是比较不同浓度的紫玉米果皮（PPE）的富含酚的水提取物在肥胖小鼠模型中的减肥效果，持续12周。40只C57BL / 6小鼠（n = 10 /组）被随机分配：标准饮食（SD），高脂饮食（HFD），HFD + 200 mg PPE / kg（200 PPE）和HFD + 500 mg PPE / kg（500 PPE）。PPE主要包含阿魏酸，花色苷和其他酚类物质（总酚类物质：448.5μg/ mg干重，DW）。与HFD组相比，500 PPE组的体重（−27.9％），血糖（−26.5％）和血液甘油三酸酯（−22.1％）衰减最大（P <.05）。另外，500组的PPE已经减少（P<.05）与HFD组相比，血浆TNF-α，MCP-1，抵抗素和瘦素的水平。HFD的脂肪肝疾病评分最高（8.4），其次是200 PPE（6.1），500 PPE（2.7）和SD（0.4）组。与HFD（12.1％）组相比，200 PPE（7.6％），500 PPE（8.0％）和SD（0.8％）的相对脂肪组织较低（P <.05）。与HFD组相比，在500 PPE组中，重要的基因被调节与脂肪形成有关（Mmp3，倍数变化[FC] = 7.4），炎症（Nfkb1， FC = -1.8）和葡萄糖代谢（Slc2a4， FC = 23.6）。脂肪组织。在肝脏中，500个PPE组显示出与糖异生相关的基因（Pck1， FC = -2.9），脂肪生成（Fasn， FC = -2.4）和β-氧化（Cpt1b，FC = 3.1）。富含阿魏酸和花色苷的玉米可通过调节TLR和AMPK信号通路来减少肥胖，从而减少脂肪形成和脂肪炎症，并促进能量消耗。