Cystic fibrosis (CF) patients are at particular risk of infection by microorganisms that are resistant to several antibiotics. About 3% of CF patients are colonized by Burkholderia cenocepacia, and this represents a major threat because of its intrinsic high level of drug resistance and the lack of a safe and effective treatment protocol. The development of anti-Burkholderia vaccines is a valuable and complementary approach, but only a few studies have been reported to date. In this review we discuss recent advances in the vaccine field and how new technologies, including structural reverse vaccinology, could drive the design of an effective vaccine against B. cenocepacia for use in preventive and therapeutic applications.

中文翻译：

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克服抗生素抗性的疫苗：Burkholderia cenocepacia的挑战。

囊性纤维化（CF）患者特别容易受到对几种抗生素具有抗性的微生物感染的风险。约3％的CF患者被伯克霍尔德菌（Bokholderia cenocepacia）定殖，这是主要威胁，因为其固有的高水平耐药性以及缺乏安全有效的治疗方案。抗伯克霍尔德氏菌疫苗的开发是一种有价值的补充方法，但迄今为止仅报道了几项研究。在这篇综述中，我们讨论了疫苗领域的最新进展，以及包括结构反向疫苗学在内的新技术如何驱动设计用于预防和治疗应用中的新城疫双歧杆菌的有效疫苗。