Transition metal-catalyzed nucleophilic addition of heteroatom nucleophiles to 1,1-difluoroallenes has been demonstrated here for the first time. Treatment of 1,1-difluoroallenes with O-nucleophiles, such as phenols, carboxylic acids, and sulfonic acids, facilitated unprecedented α-selective addition in the presence of AuCl₃ or AuCl(PPh₃)/AgSbF₆ catalysts which afforded 1,1-difluoroallyl alcohol derivatives. In contrast, amides and thiols underwent γ-selective addition to 1,1-difluoroallenes on their nitrogen or sulfur centers to provide 3,3-difluoroallyl amine and thiol derivatives.

中文翻译：

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金催化的1,1-二氟丙二烯的亲电子活化：杂原子亲核试剂的α和γ选择性加成

此处首次证明了过渡金属催化的杂原子亲核试剂向1,1-二氟丙二烯的亲核加成。在AuCl ₃或AuCl（PPh ₃）/ AgSbF ₆催化剂存在下，用O-亲核试剂（如苯酚，羧酸和磺酸）处理1,1-二氟丙二烯促进了前所未有的α-选择性加成反应，得到1,1 -二氟烯丙基醇衍生物。相反，酰胺和硫醇在它们的氮或硫中心上对1，1-二氟丙二烯进行γ-选择性加成以提供3，3-二氟烯丙基胺和硫醇衍生物。