Avenanthramides (AVA) are specific polyphenolic compounds from oats that possess several potential bioactivities. Three types of AVA from whole oats were prepared and identified, using solvent extraction coupled with HPLC-MS. Consumption of AVA at 100 and 300 mg/kg per day significantly reduced body weight gain by 9.6% and 14.8%, respectively. AVA consumption effectively improved the lipid profile; decreased serum glucose; increased activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT); and downregulated the expression of tumor necrosis factor (TNF)α, interleukin-6, and nuclear factor-кB genes. The Bacteroidetes/Firmicutes was 0.27 in high dose group, and the average relative abundance of Posteobacteria was decreased 4%, indicating that AVA effectively inhibit the obesity of C57BL/6 mice by regulating the intestinal flora, and further inhibit the growth of harmful microflora. The results indicated that AVA could alter body weight by alleviating oxidative stress and inflammation, and regulate intestinal microflora in diet-induced obesity.

Avenanthramides（AVA）是来自燕麦的特定多酚化合物，具有多种潜在的生物活性。使用溶剂萃取结合HPLC-MS制备并鉴定了三种来自全燕麦的AVA。每天摄入100和300 mg / kg的AVA可使体重增加分别显着减少9.6％和14.8％。食用AVA可有效改善脂质状况；血糖降低；增加了超氧化物歧化酶（SOD），谷胱甘肽过氧化物酶（GPx）和过氧化氢酶（CAT）的活性；并下调了肿瘤坏死因子（TNF）α，白介素6和核因子-кB基因的表达。高剂量组的拟杆菌/拟杆菌数量为0.27，后细菌的平均相对丰度降低了4％，提示AVA通过调节肠道菌群有效抑制C57BL / 6小鼠的肥胖，并进一步抑制有害菌群的生长。结果表明，AVA可以通过减轻氧化应激和炎症来改变体重，并调节饮食引起的肥胖症中的肠道菌群。