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Mechanism of a long-term controlled drug release system based on simple blended electrospun fibers.
Journal of Controlled Release ( IF 10.8 ) Pub Date : 2020-01-10 , DOI: 10.1016/j.jconrel.2020.01.020
Jiaen Wu 1 , Zixin Zhang 2 , Jin'ge Gu 3 , Weixian Zhou 1 , Xiaoyu Liang 4 , Guoqiang Zhou 5 , Charles C Han 6 , Shanshan Xu 1 , Ying Liu 4
Affiliation  

BACKGROUND Drug delivery systems based on electrospun fibers have been under development for many years. However, studies of controllable long-term drug release from electrospun membrane systems and the underlying release mechanisms have seldom been reported. METHODS In this study, electrospun membrane drug delivery systems consisting of the antibiotic ciprofloxacin hydrochloride and FDA-approved polymers are fabricated. Different second-component polymers are introduced to change the properties of a poly(d,l-lactide-co-glycolide) (PLGA) matrix, thereby altering the drug release behavior. On the basis of observations of morphology, cumulative release profiles, and determinations of release duration, the drug release kinetics and critical characteristics influencing drug release behavior are discussed. RESULTS It is found that the drug release profiles can be divided into three stages according to the rate of drug release. Stage I is controlled by fiber swelling and diffusion according to Fick's second law. Stage II is controlled by diffusion through a fused membrane structure, which results in very slow drug release. Stage III is controlled by polymer degradation and involves release of the remaining drug. CONCLUSIONS The results of this study of release mechanisms should provide a basis for adjustments of drug release dosage and duration, thereby contributing to the development of drug delivery systems satisfying clinical requirements.

中文翻译:

基于简单混合电纺纤维的长期控释系统机理。

背景技术基于静电纺丝纤维的药物递送系统已经开发了很多年。然而,很少有关于从电纺膜系统可控的长期药物释放及其潜在释放机制的研究报道。方法在本研究中,制造了由盐酸环丙沙​​星和FDA批准的聚合物组成的电纺膜药物递送系统。引入不同的第二组分聚合物以改变聚(d,1-丙交酯-乙交酯-乙交酯)(PLGA)基质的性质,从而改变药物释放行为。基于形态学观察,累积释放曲线和释放持续时间的确定,讨论了影响药物释放行为的药物释放动力学和关键特征。结果发现,根据药物释放速率,药物释放曲线可分为三个阶段。根据菲克第二定律,第一阶段由纤维溶胀和扩散控制。II期是通过融合膜结构的扩散来控制的,这导致非常缓慢的药物释放。阶段III由聚合物降解控制,涉及释放剩余的药物。结论这项释放机制的研究结果应为调整药物释放剂量和持续时间提供依据,从而有助于开发满足临床要求的药物输送系统。II期是通过融合膜结构的扩散来控制的,这导致非常缓慢的药物释放。阶段III由聚合物降解控制,涉及释放剩余的药物。结论这项释放机制的研究结果应为调整药物释放剂量和持续时间提供依据,从而有助于开发满足临床要求的药物输送系统。II期是通过融合膜结构的扩散来控制的,这导致非常缓慢的药物释放。阶段III由聚合物降解控制,涉及释放剩余的药物。结论这项释放机制的研究结果应为调整药物释放剂量和持续时间提供依据,从而有助于开发满足临床要求的药物输送系统。
更新日期:2020-01-11
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