Functionalizing black phosphorus nanosheet (BP) with efficient drug loading and endowing mesoporous silica nanomaterials with appropriate biodegradation for controllable tumor-targeted chemo-photothermal therapy are still urgent challenges. Herein, an ordered mesoporous silica-sandwiched black phosphorus nanosheet (BP@MS) with the vertical pore coating was prepared. The strategy could not only enhance the BP's dispersity and improve its doxorubicin (DOX)-loading efficiency, but also facilitate post-modification such as PEGylation and conjugation of targeting ligand, TKD peptide, yielding BSPT. A DOX-loaded BSPT-based system (BSPTD) showed heat-stimulative, pH-responsive, and sustained release manners. In vitro and in vivo results demonstrated that BSPTD had a delayed but finally complete degradation in physiological medium, contributing to an optimal therapeutic window and good biosafety. As a result, BSPTD can achieve an effective chemo-photothermal synergistic targeted therapy of tumor. Moreover, treating by BSPTD was found to be capable of remarkably inhibiting the lung metastasis of tumor, attributing to the photothermal degradation-facilitated secondary drug delivery. Our study provided a robust strategy to functionalize BP nanosheet and biodegrade the mesoporous silica for extended biomedical applications.

中文翻译：

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多功能介孔黑磷基纳米片增强的肿瘤靶向联合治疗与生物降解介导的转移抑制。

利用有效的药物负载功能化黑磷纳米片（BP）并赋予具有适当生物降解能力的介孔二氧化硅纳米材料用于可控的靶向肿瘤的化学光热疗法仍然是紧迫的挑战。在此，制备了具有垂直孔涂层的有序介孔二氧化硅夹心黑磷纳米片（BP @ MS）。该策略不仅可以增强BP的分散性并提高其阿霉素（DOX）的负载效率，而且还可以促进后修饰，例如PEG化和靶向配体TKD肽的缀合，从而产生BSPT。DOX加载的基于BSPT的系统（BSPTD）显示出热刺激，pH响应和持续释放的方式。体外和体内实验结果表明BSPTD在生理介质中具有延迟但最终完全降解的特性，有助于获得最佳的治疗窗口和良好的生物安全性。结果，BSPTD可以实现有效的肿瘤的化学-光热协同靶向治疗。此外，发现用BSPTD治疗能够显着抑制肿瘤的肺转移，归因于光热降解促进了次级药物的递送。我们的研究为将BP纳米片功能化和将中孔二氧化硅生物降解以用于扩展的生物医学应用提供了可靠的策略。