The cellular response to heat shock requires massive adaptation of gene expression driven by the transcription factor HSF1, which assembles in nuclear stress bodies together with human satellite III RNA and numerous splicing factors. In this issue of The EMBO Journal, Ninomiya et al demonstrate that nuclear stress bodies serve as a platform for phosphorylation of the SR protein SRSF9 by the CLK1 kinase, which promotes retention of a large number of introns during the recovery phase from heat shock.

中文翻译：

---

加热：核应力体发出内含子保留信号。

细胞对热休克的反应需要对转录因子HSF1驱动的基因表达进行大规模适应，转录因子HSF1与人类卫星III RNA和许多剪接因子一起组装在核应激体中。在本期《 EMBO杂志》中，Ninomiya等人证明了核应激体可作为CLK1激酶使SR蛋白SRSF9磷酸化的平台，从而促进从热激恢复阶段保留大量内含子。