BACKGROUND The manipulation of gut microbiota as a target has been suggested to reduce the risks for a number of diseases such as type 2 diabetes mellitus (T2DM). Conversely, T2DM is associated with complications such as gut and brain disorders. Furthermore, the impact of probiotics and prebiotics to improve T2DM complications are reported. Thus, the present study seeks to investigate the therapeutic and neuropsychological effects of L. plantarum and inulin in diabetic rats. METHODS Throughout the investigation, L. plantarum, inulin or their combination (synbiotic) was administered to diabetic rats. in the end, fecal samples were collected to evaluate the gut microbial composition. Then behavioral tests were conducted. Subsequently, the obtainment of the prefrontal cortex (PFC) and hippocampal samples. RESULTS Our data demonstrated that administration of L. plantarum and inulin could improve gut dysbiosis and oxidative stress status. In addition, it could ameliorate serotonin and BDNF/TrkB signaling pathway. Notably, a strong correlation between the gut microbiota changes and cognition responses was observed. Interestingly, synbiotics intake exploited a rather powerful effect on oxidative stress markers. CONCLUSION The findings confirm that there is a beneficial therapeutic potential of supplements, especially symbiotic. Moreover, neuropsychological improvement associated with balanced gut microbiome.

中文翻译：

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含合生素的植物乳杆菌对肠道微生物组的操纵对糖尿病大鼠神经心理性能的潜在治疗作用。

背景技术已经提出，以肠道菌群为靶标来降低许多疾病的风险，例如2型糖尿病（T2DM）。相反，T2DM与诸如肠道和脑部疾病等并发症相关。此外，据报道益生菌和益生元对改善T2DM并发症的影响。因此，本研究旨在研究植物乳杆菌和菊粉在糖尿病大鼠中的治疗和神经心理学作用。方法在整个调查过程中，对糖尿病大鼠施用植物乳杆菌，菊粉或其组合（合生元）。最后，收集粪便样品以评估肠道微生物组成。然后进行行为测试。随后，获得前额叶皮层（PFC）和海马样本。结果我们的数据表明，施用植物乳杆菌和菊粉可以改善肠道营养不良和氧化应激状态。此外，它可以改善血清素和BDNF / TrkB信号通路。值得注意的是，观察到肠道菌群变化与认知反应之间存在很强的相关性。有趣的是，合生素的摄入对氧化应激标志物具有相当强大的作用。结论该发现证实补充剂，特别是共生体具有有益的治疗潜力。此外，与肠道微生物平衡有关的神经心理改善。观察到肠道菌群变化与认知反应之间存在很强的相关性。有趣的是，合生素的摄入对氧化应激标志物具有相当强大的作用。结论该发现证实补充剂，特别是共生体具有有益的治疗潜力。此外，与肠道微生物平衡有关的神经心理改善。观察到肠道菌群变化与认知反应之间存在很强的相关性。有趣的是，合生素的摄入对氧化应激标志物具有相当强大的作用。结论该发现证实补充剂，特别是共生体具有有益的治疗潜力。此外，与平衡肠道微生物组有关的神经心理改善。