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Associations between manganese exposure and multiple immunological parameters in manganese-exposed workers healthy cohort.
Journal of Trace Elements in Medicine and Biology ( IF 3.5 ) Pub Date : 2020-01-10 , DOI: 10.1016/j.jtemb.2020.126454
Xiang Chen 1 , Zhenfang Liu 2 , Xiaoting Ge 1 , Xiaoyu Luo 1 , Sifang Huang 1 , Yanting Zhou 1 , Defu Li 1 , Hong Cheng 1 , Longman Li 1 , Lulu Huang 1 , Qingzhi Hou 1 , Gaohui Zan 1 , Yanli Tan 1 , Chaoqun Liu 3 , Yunfeng Zou 4 , Xiaobo Yang 5
Affiliation  

BACKGROUND Manganese (Mn) ions play a crucial role in the immune response. The immunotoxicity of Mn is rarely reported compared with the neurotoxicity of Mn. OBJECTIVES The purpose of this study was to investigate the associations between chronic Mn exposure and immunological parameters in occupational Mn-exposed workers. METHODS A total of 538 workers were selected from the follow-up of manganese-exposed workers healthy cohort (MEWHC) in 2017. We divided the workers into the low-exposure group and the high-exposure group by the cutoff of the manganese-time weighted average (Mn-TWA) setting at 0.15 mg/m3. We examined serum immunological parameters by the immunoturbidimetric method and leukocyte counts and ratios in blood routine. Then we used the generalized linear model analyses and spline analyses to explore the associations between external exposure of Mn and multiple immunological parameters adjusted for variables. Based on the epidemiological analyses, we used Elisa (enzyme-linked immune sorbent assay) to detect plasma complement C3 of Mn-exposed rats. RESULTS In male workers, the mean value of complement C3 was 1.20 ± 0.16 g/L in the high-exposure group, which was significantly lower as compared to the low-exposure group (1.25 ± 0.18 g/L, P = 0.023). The generalize linear models' analyses showed that complement C3 value had a significantly negative association with external exposure of Mn included adjustment for variables (β = -0.04, P = 0.035). Moreover, in male rats, the high-exposure group also had a lower level of complement C3 compared with the low-exposure group (P < 0.001). None significant association was observed in immunological parameters among female workers and rats (all P > 0.05). CONCLUSIONS Mn exposure from inhalable dust was associated with decreased complement C3 among occupationally Mn-exposed male individuals but not in female workers, which was further confirmed by the rat model. Further research into the possible mechanism of C3 reduction is needed in the future.

中文翻译:

锰暴露工人健康队列中锰暴露与多种免疫学参数之间的关联。

背景技术锰(Mn)离子在免疫应答中起关键作用。与Mn的神经毒性相比,很少报道Mn的免疫毒性。目的本研究的目的是调查职业性锰暴露工人中慢性锰暴露与免疫学参数之间的关系。方法从2017年锰暴露工人健康队列(MEWHC)的随访中选出538名工人。按照锰时间的截止时间,将工人分为低暴露组和高暴露组。加权平均(Mn-TWA)设置为0.15 mg / m3。我们通过免疫比浊法和血液常规中的白细胞计数和比率检查了血清免疫学参数。然后,我们使用广义线性模型分析和样条分析来探讨Mn的外部暴露与针对变量调整的多个免疫学参数之间的关联。基于流行病学分析,我们使用Elisa(酶联免疫吸附测定)检测了Mn暴露大鼠的血浆补体C3。结果在男性工人中,高暴露组中补体C3的平均值为1.20±0.16 g / L,比低暴露组(1.25±0.18 g / L,P = 0.023)低得多。广义线性模型的分析表明,补体C3值与Mn的外部暴露显着负相关,包括对变量的调整(β= -0.04,P = 0.035)。而且,在雄性老鼠中 高暴露组的补体C3水平也低于低暴露组(P <0.001)。在女性工人和大鼠之间,免疫学参数均未发现显着相关性(所有P> 0.05)。结论吸入性粉尘中锰的暴露与职业性锰暴露的男性个体中补体C3的减少有关,而女性工作者却没有,这在大鼠模型中得到了进一步证实。未来需要进一步研究减少C3的可能机制。大鼠模型进一步证实了这一点。未来需要进一步研究减少C3的可能机制。大鼠模型进一步证实了这一点。未来需要进一步研究减少C3的可能机制。
更新日期:2020-01-11
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