Life course adiposity and amyotrophic lateral sclerosis: a Mendelian randomization study,Annals of Neurology

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Life course adiposity and amyotrophic lateral sclerosis: a Mendelian randomization study
Annals of Neurology ( IF 11.2 ) Pub Date : 2020-01-21 , DOI: 10.1002/ana.25671
Linjing Zhang ₁ , Lu Tang ₁ , Tao Huang _{2,

3} , Dongsheng Fan _{1,

4}

Affiliation

Observational studies have indicated that life course adiposity is associated with amyotrophic lateral sclerosis (ALS). However, whether such an association reflects causality remains unclear. We aimed to determine whether life course adiposity such as birth weight (BW), childhood body mass index (BMI), adult BMI, body fat percentage (BF%), and waist‐to‐hip ratio (WHR) have causal effects on ALS.

中文翻译：

生命历程肥胖和肌萎缩侧索硬化：孟德尔随机化研究

观察性研究表明，生命历程中的肥胖与肌萎缩侧索硬化 (ALS) 相关。然而，这种关联是否反映了因果关系尚不清楚。我们旨在确定出生体重 (BW)、儿童体重指数 (BMI)、成人 BMI、体脂百分比 (BF%) 和腰臀比 (WHR) 等生命历程肥胖是否对 ALS 有因果影响.

更新日期：2020-01-21

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