Angiogenesis represents a hallmark of cancer. Several proteoglycans associate with cell surface receptors and regulate angiogenesis within the tumor microenvironment (TME). We highlight the recent discovery that the proteoglycan Agrin cross talks between the tumor and the endothelium to promote an angiogenesis privileged niche during cancer progression.

中文翻译：

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Agrin介导肿瘤微环境中的血管生成。

血管生成代表癌症的标志。几种蛋白聚糖与细胞表面受体结合并调节肿瘤微环境（TME）内的血管生成。我们强调了最近的发现，即蛋白聚糖Agrin在肿瘤和内皮之间串扰，从而在癌症进展过程中促进了血管生成的优先地位。