Considering the importance of metal complexes in the development of medical science, two different Schiff base Fe(II) and Co(II) metal complex compounds were synthesized with Schiff base obtained through the condensation of 1-(4-aminophenyl)ethanone with 2-hydroxy-3-methoxybenzaldehyde. The reactions of the ligand with Co(II) and Fe(II) metal ions enabled six coordination compounds with octahedral geometries. The novel metal complexes were characterized by IR, elemental analyses, magnetic susceptibility, mass spectra, UV–Vis, thermogravimetry–differential thermal analysis (TGA–DTA) and X-ray diffraction analysis. The antioxidant properties of the new compounds were investigated using different in vitro assays. Moreover, enzyme inhibition of derivatives complexes against carbonic anhydrase I and II isoenzymes (CA I and II) and acetylcholinesterase (AChE) was evaluated. The best inhibitor complex for CA I and II isoenzymes was the Fe(II) complex with K_i values of 52.83 ± 11.52 and 63.34 ± 8.88, respectively.

考虑到金属配合物在医学发展中的重要性，利用1-（4-氨基苯基）乙酮与2-的缩合反应制得的席夫碱合成了两种不同的席夫碱Fe（II）和钴（II）金属配合物化合物。羟基-3-甲氧基苯甲醛。配体与Co（II）和Fe（II）金属离子的反应使六配位化合物具有八面体几何形状。通过IR，元素分析，磁化率，质谱，UV-Vis，热重分析-差热分析（​​TGA-DTA）和X射线衍射分析对新型金属配合物进行表征。使用不同的体外试验研究了新化合物的抗氧化性能。此外，评估了衍生物配合物对碳酸酐酶I和II同功酶（CA I和II）和乙酰胆碱酯酶（AChE）的酶抑制作用。CA I和II同工酶的最佳抑制剂配合物是Fe（II）配合物K _i值分别为52.83±11.52和63.34±8.88。