A sustained release of anti-infection drugs is beneficial for the reduction of required dressing change times and the protection of the granulation tissue against further infection. In this work, the strategy of encapsulating mesoporous SBA-15 particles in a permeable cellulose membrane (CM) was used in the preparation of antibacterial cellulose based composite membranes to depot store and deliver drugs with prolonged anti-microbial drug release characteristics. It was found that SBA-15 with the protection of phosphate buffered saline prefilled in SBA-15 mesoporous channel could resist strong alkali environment during composite membranes preparation and its mesoporous structure remained intact, which was verified by SEM, TEM and BET results. The resultant cellulose based composite membrane containing 30 wt% SBA-15 (denoted as P-CM-SBA (30%)) had achieved 3.6 wt% drug loading and demonstrated the sustained release of chloramphenicol for 250 h, which was resulted from SBA-15/cellulose structure-inducing two-stage release behavior. Strong antibacterial activity of P-CM-SBA (30%) against S. aureus and E. coli. could last 144 h. In addition, the tensile strength, water vapor transmission rate and swelling properties of P-CM-SBA (30%) conformed to the primary requirements of wound dressing materials. Therefore, cellulose based composite membrane with 30 wt% SBA-15 particles possesses the potential for the application of wound healing.

中文翻译：

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多孔SBA-15 /纤维素膜具有延长的抗微生物药物释放特性，可用于潜在的伤口敷料应用

持续释放抗感染药物有利于减少所需的敷料更换时间并保护肉芽组织免受进一步感染。在这项工作中，将中孔SBA-15颗粒包裹在可渗透纤维素膜（CM）中的策略用于制备基于抗菌纤维素的复合膜，以贮存和递送具有延长的抗微生物药物释放特性的药物。结果表明，在复合膜制备过程中，预先填充在SBA-15介孔通道中的磷酸缓冲盐水保护的SBA-15在复合膜制备过程中具有较强的耐碱性环境，并通过SEM，TEM和BET测试证实了其介孔结构的完整性。所得的包含30 wt％SBA-15（表示为P-CM-SBA（30％））的纤维素基复合膜已达到3.6 wt％的载药量，并证明氯霉素可持续释放250小时，这是由SBA- 15 /纤维素结构诱导两阶段释放行为。P-CM-SBA的强抗菌活性（30％）对金黄色葡萄球菌和大肠杆菌。可能持续144小时。此外，P-CM-SBA（30％）的拉伸强度，水蒸气透过率和溶胀性能符合伤口敷料的主要要求。因此，具有30wt％的SBA-15颗粒的纤维素基复合膜具有应用伤口愈合的潜力。