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Evaluation of channel-like porous-structured titanium in mechanical properties and osseointegration
Journal of Materials Science & Technology ( IF 10.9 ) Pub Date : 2020-01-08 , DOI: 10.1016/j.jmst.2019.10.026
Dong Wang , Guo He , Ye Tian , Ning Ren , Jiahua Ni , Wei Liu , Xianlong Zhang

The porous titanium with a channel-like pore structure fabricated by infiltration casting followed by selectively dissolving the precursor woven three dimensional (3D) structure technique was comprehensively investigated by means of mechanical tests, in vitro and in vivo evaluation. Such porous structure exhibited superiority in compressive, tensile strength and osseointegration. At 40% porosity, the average compressive and tensile strength reached about 145 MPa and 85 MPa, which was superior to that of other porous titanium, e.g., Selective Laser Melting or powder sintered ones, and was comparable to that of the human cortical bone. Without any bioactive surface treatment, this porous titanium exhibited good cell adhesion, rapid cell proliferation and excellent osseointegration. Based on the study, the 0.4 mm pore size resulted in the most rapid cell proliferation and the maximal BV/TV ratio and trabecular bone number of the new bone that ingrew into the porous titanium. To balance the excellent osseointegration and adequate mechanical properties, the optimal structural parameters were 0.4 mm pore size with 40% porosity. This porous titanium is very promising for orthopedic applications where compressive and tensile load-bearing is extremely important.



中文翻译:

通道状多孔结构钛的力学性能和骨整合评价

通过机械测试,体外和体内评估,全面研究了通过渗透浇铸,然后选择性地溶解前体编织三维(3D)结构技术制造的具有通道状孔结构的多孔钛。这种多孔结构在抗压,抗张强度和骨整合方面显示出优越性。在孔隙率为40%时,平均抗压强度和拉伸强度分别达到145 MPa和85 MPa,优于其他多孔钛,例如,选择性激光熔炼或粉末烧结的钛,并且与人的皮质骨相当。未经任何生物活性表面处理,这种多孔钛表现出良好的细胞粘附性,快速的细胞增殖和出色的骨整合。根据研究,该值为0。4 mm的孔径导致最快速的细胞增殖以及最大的BV / TV比和进入多孔钛中的新骨的小梁骨数。为了平衡出色的骨整合性和足够的机械性能,最佳的结构参数是孔径为0.4 mm,孔隙率为40%。这种多孔钛对于在抗压和抗拉承重极为重要的整形外科应用中非常有前途。

更新日期:2020-01-08
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