This study aims to explore the analgesic and anti-inflammatory effects of borneol, a traditional Chinese medicine, on photodynamic treatment of acne. Here, we found that borneol significantly decreased the auricular swelling rate and pain threshold of rats. We also showed that borneol noticeably reduced macrophage and lymphocyte infiltration. The number of Th cells was significantly higher in the control PDT group than in the PDT plus borneol treatment group (P < 0.05). The expression of IL-6, TNF-α, and IL-8 mRNA and proteins were noticeably lower in the treatment group in comparison to those of the PDT control group, while PDT plus borneol activated the p38-COX-2-PGE2 signaling pathway, increasing expression in the treatment group. Borneol has significant analgesic and anti-inflammatory effects on PDT of acne, and enhances the healing of acne by activating p38-COX-2-PGE2 signaling pathway.

本研究旨在探讨中药冰片对痤疮的光动力治疗的镇痛和抗炎作用。在这里，我们发现冰片显着降低了大鼠的耳肿胀率和疼痛阈值。我们还表明，冰片可明显减少巨噬细胞和淋巴细胞浸润。对照PDT组中的Th细胞数量显着高于PDT加冰片治疗组（P <0.05）。与PDT对照组相比，治疗组中IL-6，TNF-α和IL-8 mRNA和蛋白的表达明显降低，而PDT加冰片则激活了p38-COX-2-PGE2信号通路。 ，增加治疗组的表达。冰片对痤疮的PDT具有明显的镇痛和抗炎作用，