Regeneration involves regulating tissue proportionality across considerable size ranges through unknown mechanisms. In planarians, which scale reversibly over 40× through regeneration, we identify the Striatin-interacting phosphatase and kinase (STRIPAK) complex as a potent negative regulator of axis length. Inhibition of two proteins in the STRIPAK complex, mob4 and striatin, dramatically increased posterior length, through expansion of a posterior wnt1+ signaling center within midline muscle cells. wnt1 was required for tail expansion after mob4 inhibition and dynamically reestablishes proportionality after amputation in normal animals, indicating STRIPAK represses Wnt signaling for scaling. Regulation of wnt1 expansion was stem cell dependent, demonstrating that control of signaling-center production through stem cell differentiation underlies proportional growth in adult regenerative tissue.

中文翻译：

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STRIPAK限制WNT信号中心的干细胞分化，以控制平面轴缩放。

再生涉及通过未知机制在相当大的范围内调节组织比例。在通过再生可逆地缩放40倍以上的涡虫中，我们将Striatin相互作用的磷酸酶和激酶（STRIPAK）复合物确定为有效的轴长负调节剂。STRIPAK复合物中的两种蛋白质，mob4和striatin的抑制通过中线肌肉细胞内wnt1 +信号后中心的扩展而大大增加了后长度。mob4抑制后，尾巴扩张需要wnt1，并且在正常动物截肢后需要wnt1动态重新建立比例，这表明STRIPAK抑制了Wnt信号的结垢。wnt1扩增的调控取决于干细胞，