Epigenetic regulation plays an important role in controlling the activation, timing, and resolution of innate immune responses in macrophages. Previously, SWI/SNF chromatin remodeling was found to define the kinetics and selectivity of gene activation in response to microbial ligands; however, these studies do not reflect a comprehensive understanding of SWI/SNF complex regulation. In 2018, a new variant of the SWI/SNF complex was identified with unknown function in inflammatory gene regulation. Here, we summarize the biochemical and genomic properties of SWI/SNF complex variants and the potential for increased regulatory control of innate immune transcriptional programs in light of such biochemical diversity. Finally, we review the development of SWI/SNF complex chemical inhibitors and degraders that could be used to modulate immune responses.

中文翻译：

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SWI/SNF 染色质重塑复合物对巨噬细胞刺激依赖性反应的控制。

表观遗传调控在控制巨噬细胞先天免疫反应的激活、时间和消退方面起着重要作用。以前，发现 SWI/SNF 染色质重塑定义了响应微生物配体的基因激活的动力学和选择性；然而，这些研究并没有反映出对 SWI/SNF 复杂监管的全面理解。2018 年，SWI/SNF 复合体的一个新变体被发现在炎症基因调控中具有未知功能。在这里，我们总结了 SWI/SNF 复杂变体的生化和基因组特性，以及根据这种生化多样性加强对先天免疫转录程序的监管控制的潜力。最后，我们回顾了可用于调节免疫反应的 SWI/SNF 复合化学抑制剂和降解剂的开发。