We report the preparation and characterization of five new [60]fullerene derivatives formed in the novel reaction of C₆₀Cl₆ with dimethyl 2,2'-(1,4-phenylenebis-(oxy))diacetate, which were isolated by preparative HPLC and characterized by APCI-MS, ¹H, ¹³C, and 2D NMR spectroscopy. Acidic hydrolysis of the ester groups in the synthesized compounds produced a series of water-soluble fullerene derivatives, which demonstrated pronounced activities against Human Immunodeficiency Virus (HIV) replication. Correlations between the structures of the fullerene derivatives and their antiviral activity were established.

中文翻译：

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C ₆₀ Cl ₆与对苯二酚醚反应获得的多元羧酸[60]富勒烯衍生物的合成，表征和抗HIV活性

我们报告了五个新的[60]富勒烯衍生物的制备和表征，这些衍生物在C ₆₀ Cl ₆与2,2'-（1,4-亚苯基双-（氧基））二乙酸二甲酯的新型反应中形成，并通过制备型HPLC进行了分离并通过APCI-MS，¹ H，¹³ C和2D NMR光谱进行表征。合成化合物中酯基的酸性水解产生了一系列水溶性富勒烯衍生物，其表现出明显的抗人类免疫缺陷病毒（HIV）复制的活性。建立了富勒烯衍生物的结构与其抗病毒活性之间的关系。