The basolateral amygdala (BLA) plays a vital role in associating sensory stimuli with salient valence information. Excitatory principal neurons (PNs) undergo plastic changes to encode this association; however, local BLA inhibitory interneurons (INs) gate PN plasticity via feedforward inhibition (FFI). Despite literature implicating parvalbumin expressing (PV⁺) INs in FFI in cortex and hippocampus, prior anatomical experiments in BLA implicate somatostatin expressing (Sst⁺) INs. The lateral entorhinal cortex (LEC) projects to BLA where it drives FFI. In the present study, we explored the role of interneurons in this circuit. Using mice, we combined patch clamp electrophysiology, chemogenetics, unsupervised cluster analysis, and predictive modeling and found that a previously unreported subpopulation of fast-spiking Sst⁺ INs mediate LEC→BLA FFI.

中文翻译：

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通过内嗅皮质驱动的前馈抑制来控制基底外侧杏仁核神经元回路的细胞类型特异性控制

基底外侧杏仁核（BLA）在将感觉刺激与显着价信息相关联中起着至关重要的作用。兴奋性主要神经元（PNs）发生塑性变化，以编码这种关联。但是，局部BLA抑制性神经元（INs）通过前馈抑制（FFI）可以控制PN可塑性。尽管有文献暗示皮质和海马FFI中表达小白蛋白（PV ⁺）INs，但先前BLA的解剖学实验暗示生长抑素表达（Sst ⁺）IN。内嗅皮层（LEC）伸向BLA，驱动FFI。在本研究中，我们探索了中间神经元在该电路中的作用。使用小鼠，我们结合了膜片钳电生理学，化学遗传学，无监督的聚类分析和预测模型，发现以前未报道的快速加标Sst ⁺ INs亚群介导了LEC→BLA FFI。