Enantioselective separation is significantly important for the study of pharmacology and biology, but it is still a big challenge because of the identical physical and chemical properties of enantiomers in an achiral environment. Magnetic nanomaterials have unique properties such as extremely large surface area per volume substance and strong magnetic response. It is very easy for them to be isolated from complicated matrixes, only by applying external magnets. The possibilities for surface functionalization make them exciting candidates for enantioseparation. Functionalized magnetic nanomaterials are unique tools for the simple and rapid enantioseparation compared with traditional chiral stationary phase. In this review, various magnetic nanomaterials modified with specific chiral selectors are reviewed in this manuscript. The prepared functional magnetic materials are typically used as chiral adsorbents for enantioseparation applications, formatted by methods of dispersive solid phase extraction, enantioselective crystallization, or column and microchip separation.

对映选择性分离对于药理学和生物学研究非常重要，但由于在非手性环境中对映异构体具有相同的物理和化学性质，它仍然是一个很大的挑战。磁性纳米材料具有独特的特性，例如每单位表面积非常大体积大，磁响应强。仅通过施加外部磁体，很容易将它们与复杂的矩阵隔离。表面功能化的可能性使其成为对映体分离的令人兴奋的候选对象。与传统的手性固定相相比，功能化的磁性纳米材料是用于简单快速对映体分离的独特工具。在这篇综述中，本手稿对用特定手性选择剂改性的各种磁性纳米材料进行了综述。制备的功能性磁性材料通常用作对映体分离应用的手性吸附剂，通过分散固相萃取，对映体选择性结晶或柱与微芯片分离的方法进行格式化。