Anti-biofouling treatment is required in various fields such as biomedical application, construction, civil engineering, and so on. Currently available techniques such as lithography and replica methods have several limitations in application and accessibility. We introduced a simple, biocompatible, and cost-effective anti-biofouling dip-coating method with polyurethane-inorganic (anisotropic montmorillonite and spherical TiO2) hybrid coating agent. Layer thickness of coating was as thin as 5 μm. It was cross-confirmed with thickness gauge and cross-section scanning electron microscopy. Through atomic force microscopy, inorganic nanoparticles were observed to be randomly arrayed with particles partially embedded in the polyurethane network. The calculated surface roughness of inorganic-polyurethane hybrid coating was five times larger than the neat substrate film and three times larger than coating without inorganic nanoparticles. Surface energy of the inorganic-polyurethane film decreased with increasing surface roughness as random pattern of inorganic particle reduced van der Waals interaction. Biofouling efficacy was evaluated by mucin adsorption and consecutive alcian blue assay. Results showed that coated film decreased biofouling 81% compared to bare film.

中文翻译：

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无机纳米粒子在聚合物表面的无规排列，可通过具有成本效益的高性能浸涂实现抗生物结垢性能。

生物医学应用，建筑，土木工程等各个领域都需要进行防生物污垢处理。诸如光刻和复制方法之类的当前可用技术在应用程序和可访问性方面有一些限制。我们介绍了一种简单，生物相容且经济高效的防污垢浸涂方法，该方法采用聚氨酯-无机（各向异性蒙脱土和球形TiO2）杂化涂料。涂层的层厚度薄至5μm。通过厚度计和截面扫描电子显微镜对其进行交叉确认。通过原子力显微镜观察，观察到无机纳米颗粒随机排列有部分嵌入聚氨酯网络的颗粒。计算得到的无机-聚氨酯杂化涂层的表面粗糙度是纯底材膜的五倍，是没有无机纳米粒子的涂层的三倍。无机-聚氨酯膜的表面能随着表面粗糙度的增加而降低，因为无机颗粒的无规图案降低了范德华相互作用。通过粘蛋白吸附和连续的阿尔辛蓝测定法评估生物污垢效力。结果表明，涂​​膜与裸膜相比减少了81％的生物污染。通过粘蛋白吸附和连续的阿尔辛蓝测定法评估生物污垢效力。结果表明，涂​​膜与裸膜相比减少了81％的生物污染。通过粘蛋白吸附和连续的阿尔辛蓝测定法评估生物污垢效力。结果表明，涂​​膜与裸膜相比减少了81％的生物污染。