当前位置: X-MOL 学术Annu. Rev. Pharmacol. Toxicol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Emerging Pharmacological Treatments for Cerebral Edema: Evidence from Clinical Studies.
Annual Review of Pharmacology and Toxicology ( IF 12.5 ) Pub Date : 2020-01-08 , DOI: 10.1146/annurev-pharmtox-010919-023429
Jesse A Stokum 1 , Volodymyr Gerzanich 1 , Kevin N Sheth 2 , W Taylor Kimberly 3 , J Marc Simard 1, 4
Affiliation  

Cerebral edema, a common and often fatal companion to most forms of acute central nervous system disease, has been recognized since the time of ancient Egypt. Unfortunately, our therapeutic armamentarium remains limited, in part due to historic limitations in our understanding of cerebral edema pathophysiology. Recent advancements have led to a number of clinical trials for novel therapeutics that could fundamentally alter the treatment of cerebral edema. In this review, we discuss these agents, their targets, and the data supporting their use, with a focus on agents that have progressed to clinical trials.

中文翻译:

脑水肿的新兴药理治疗:来自临床研究的证据。

自古埃及时代以来,人们就已经认识到脑水肿是大多数形式的急性中枢神经系统疾病的常见且通常致命的伴侣。不幸的是,我们的治疗装备仍然有限,部分原因是由于我们对脑水肿病理生理学的了解存在历史性限制。最近的进展导致了许多新疗法的临床试验,这些疗法可以从根本上改变脑水肿的治疗方法。在这篇综述中,我们讨论了这些药物,它们的靶标以及支持其使用的数据,重点是已进行到临床试验的药物。
更新日期:2020-04-21
down
wechat
bug