Mechanically interlocked molecules have marked a breakthrough in the field of topological chemistry and boosted the vigorous development of molecular machinery. As an archetypal example of the interlocked molecules, catenanes comprise macrocycles that are threaded through one another like links in a chain. Inspired by the transition metal-templated approach of catenanes synthesis, the hierarchical assembly of DNA origami catenanes templated by gold nanoparticles is demonstrated in this work. DNA origami catenanes, which contain two, three or four interlocked rings are successfully created. In particular, the origami rings within the individual catenanes can be set free with respect to one another by releasing the interconnecting gold nanoparticles. This work will set the basis for rich progress toward DNA-based molecular architectures with unique structural programmability and well-defined topology.

中文翻译：

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金纳米颗粒为模板的DNA折纸链环。

机械互锁的分子标志着拓扑化学领域的突破，并促进了分子机械的蓬勃发展。作为互锁分子的一个典型例子，链烷烃包括大环，它们像链中的链节一样彼此穿过。受到链烷烃合成的过渡金属模板化方法的启发，这项工作证明了以金纳米颗粒为模板的DNA折纸链烷烃的分层组装。成功创建了包含两个，三个或四个互锁环的DNA折纸链环。特别地，可以通过释放相互连接的金纳米颗粒而使各个连环内的折纸环相对于彼此自由。