Due to the increasing scientific and biomedical interest in various nanoparticles (NPs) with excellent properties and the onset of their commercial use, a convenient and adjustable physical method for improved efficiency needs to be used for enabling their tech-scale production. Recently, great progress has been made in the large-scale production of NPs with a simple structure by pulsed laser ablation in liquid (PLAL). In this work, we synthesized gold-silica core-shell NPs by improved PLAL and provided a guide on how to investigate their physico-chemical properties and association with biological effects towards cancer photothermal therapy (PTT). By means of this method, reproducible and scalable liquid phase NPs with less toxicity and good stability can be realized for tech-scale production based on its further adjustment and modification. Moreover, a more complete investigation of the associations between the physico-chemical properties of functional NPs with complex structure and their biological effects may enable more targeted NPs towards specific requirements of biomedical applications.

中文翻译：

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脉冲激光烧蚀在液体中合成金-硅核-壳纳米粒子及其对光热癌症治疗的理化性质。

由于对具有优异性能的各种纳米颗粒（NP）的科学和生物医学兴趣日益增长，并且开始将其商业化使用，因此需要使用一种方便且可调节的物理方法来提高效率，以实现其技术规模的生产。近来，通过脉冲激光烧蚀液体（PLAL），以简单的结构大规模生产NPs已经取得了很大的进步。在这项工作中，我们通过改进的PLAL合成了金-二氧化硅核-壳NP，并提供了有关如何研究其​​理化性质以及与对癌症光热疗法（PTT）的生物学效应的关联的指南。通过这种方法，可以通过对其进一步的调整和改进，实现毒性较小，稳定性好的可再生，可扩展的液相纳米颗粒，用于技术规模的生产。