Elevated Extracellular Free-Water in a Multicentric First-Episode Psychosis Sample, Decrease During the First 2 Years of Illness.,Schizophrenia Bulletin

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Elevated Extracellular Free-Water in a Multicentric First-Episode Psychosis Sample, Decrease During the First 2 Years of Illness.
Schizophrenia Bulletin ( IF 6.6 ) Pub Date : 2020-01-09 , DOI: 10.1093/schbul/sbz132
Daniel Bergé _{1,

2,

3} , Anna Mané _{1,

2,

3} , Tyler A Lesh ₄ , Miquel Bioque ₅ , Fe Barcones _{6,

7,

8} , Ana Maria Gonzalez-Pinto _{3,

9,

10} , Mara Parellada _{3,

11} , Eduard Vieta _{3,

12} , Josefina Castro-Fornieles _{3,

13} , Roberto Rodriguez-Jimenez _{3,

14} , Maria Paz García-Portilla ₁₅ , Judith Usall ₁₆ , Cameron S Carter ₄ , Bibiana Cabrera _{3,

5} , Miguel Bernardo _{3,

5} , Joost Janssen _{3,

17,

18} ,

Affiliation

Neuroscience Department, Neuroimaging Group, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
Department of Psychiatry and Forensic Medicine, Autonomous University of Barcelona, Bellaterra, Spain.
CIBERSAM, Madrid, Spain.
Department of Psychiatry and Behavioral Sciences, University of California at Davis (UCDAVIS), Sacramento, CA.
Schizophrenia Unit, Hospital Clínic Barcelona, Barcelona, Spain.
Department of Psychiatry, Instituto Aragonés de Ciencias de la Salud, Zaragoza, Spain.
Department of Family Medicine, Hospital Universitario Miguel Servet, Zaragoza, Spain.
Department of Medicine and Psychiatry, University of Zaragoza, Zaragoza, Spain.
BioAraba Health Research Institute, Vitoria-Gasteiz, Spain.
Department of Neuroscience, University of the Basque Country, Leioa, Spain.
Child and Adolescent Psychiatry, Hospital Gregorio Marañon, Madrid, Spain.
Bipolar and Depressive Disorders Unit, Hospital Clínic Barcelona, University of Barcelona, Barcelona, Spain.
Department of Child and Adolescent Psychiatry and Psychology, IDIBAPS, Hospital Clínic Barcelona, Barcelona, Spain.
Department of Cognition and Psychosis, Instituto de Investigación Sanitaria 12 de Octubre (imas12), Madrid, Spain.
Department of Psychiatry, University of Oviedo, Oviedo, Spain.
Research and Development Unit, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Spain.
Child and Adolescent Psychiatry, Hospital Universitario Gregorio Marañon, Madrid, Spain.
Brain Center Rudolf Magnus, UMC Ultrecht, Ultrecht, The Netherlands.

Recent diffusion imaging studies using free-water (FW) elimination have shown increased FW in gray matter (GM) and white matter (WM) in first-episode psychosis (FEP) and lower corrected fractional anisotropy (FAt) in WM in chronic schizophrenia. However, little is known about the longitudinal stability and clinical significance of these findings.

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