Patients with atopic asthma may become sensitised to the grain storage mite Dermatophagoides farinae (Der f), the house dust mite Dermatophagoides pteronyssinus (Der p) or both, but thus far little attention has been paid to date to possible variation in their pathophysiological effects. Here we present a side by side comparison of the effects of extracts of these two dust mites in a murine surrogate of atopic asthma. Compared with the Der p-challenged mice, however, the mice-challenged with Der f had favour changes in lung tissue elasticity and expression in matrix metalloproteinases in lung tissue, while the mice challenged with Der p showed more neutrophils infiltrating around the airway and stronger expression of steroid-resistant related cytokines in the lung tissue. Our data suggest that different dust mite crude extracts might lead different pathological characteristics, at least in murine models of asthma.

中文翻译：

---

在小鼠哮喘替代物中，对法氏皮肤癣菌（Dermatophagoides farinae）和蕨类皮肤癣菌（Dermatophagoides pteronyssinus）提取物的致敏和激发作用的异同。

患有特应性哮喘的患者可能对谷粒螨Dermatophagoides farinae（Der f），屋尘螨Dermatophagoides pteronyssinus（Der p）或两者同时过敏，但迄今为止，对其病理生理作用可能存在的变化几乎没有引起注意。在这里，我们提出了这两种尘螨提取物在特应性哮喘的小鼠替代物中的作用的并排比较。与受Der p攻击的小鼠相比，受Der f攻击的小鼠的肺组织弹性变化和肺组织中基质金属蛋白酶的表达有利，而受Der p攻击的小鼠表现出更多的中性粒细胞浸润到气道周围并且更强类固醇抗性相关细胞因子在肺组织中的表达