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Apoptotic cell-derived exosomes: messages from dying cells.
Experimental & Molecular Medicine ( IF 12.8 ) Pub Date : 2020-01-09 , DOI: 10.1038/s12276-019-0362-8
Ramesh Kakarla 1, 2 , Jaehark Hur 1, 2 , Yeon Ji Kim 1, 2 , Jaeyoung Kim 3 , Yong-Joon Chwae 1, 2
Affiliation  

Apoptosis, a type of programmed cell death that plays a key role in both healthy and pathological conditions, releases extracellular vesicles such as apoptotic bodies and microvesicles, but exosome release due to apoptosis is not yet commonly accepted. Here, the reports demonstrating the presence of apoptotic exosomes and their roles in inflammation and immune responses are summarized, together with a general summary of apoptosis and extracellular vesicles. In conclusion, apoptosis is not just a 'silent' type of cell death but an active form of communication from dying cells to live cells through exosomes.

中文翻译:

凋亡细胞衍生的外泌体:来自垂死细胞的信息。

细胞凋亡是一种程序性细胞死亡,在健康和病理条件下都起着关键作用,它会释放细胞外囊泡,例如凋亡小体和微泡,但细胞凋亡引起的外泌体释放尚未被普遍接受。在这里,总结了证明凋亡外泌体的存在及其在炎症和免疫反应中的作用的报告,以及细胞凋亡和细胞外囊泡的一般总结。总之,细胞凋亡不仅仅是一种“沉默”类型的细胞死亡,而是一种通过外泌体将垂死细胞与活细胞进行交流的活跃形式。
更新日期:2020-01-09
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