The infection of Xanthomonas oryzae pv. Oryzae (Xoo), Ralstonia solanacearum (Rs), and Xanthomonas axonopodis pv. Citri (Xac) has become a major problem in agricultural production. In this study, a series of novel chalcone derivatives containing thioether triazoles were designed and synthesized. The structures of the novel compounds were systematically characterized via ¹H‐NMR, ¹³C‐NMR, and HRMS. Moreover, the antibacterial activity results showed that E₁₀, E₁₁, E₁₅, and E₁₆ have adequate antibacterial activities against Xoo, Rs, and Xac. Among the different compounds, E₁₅ exhibited remarkable inhibitory effect against Xac with an EC₅₀ of 9.1 μg.mL^‐1, which was better than that of commercial agent bismerthiazol (54.9 μg.mL^‐1). In addition, the possible antibacterial mechanism of the target compound E₁₅ against Xac was studied via scanning electron microscopy (SEM).

中文翻译：

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含硫醚三唑查尔酮衍生物的合成及抑菌活性

米糠黄单胞菌的感染。Oryzae（Xoo），Ralstonia solanacearum（Rs）和Xanthomonas axonopodis pv。柠檬（Xac）已成为农业生产中的主要问题。在这项研究中，设计并合成了一系列新型的含硫醚三唑的查尔酮衍生物。通过 ¹ H-NMR，¹³ C-NMR和HRMS系统地表征了新型化合物的结构。此外，抗菌活性结果表明，E ₁₀，E ₁₁，E ₁₅和E ₁₆对Xoo，Rs和Xac具有足够的抗菌活性。在不同的化合物中，E ₁₅对Xac表现出显着的抑制作用，EC ₅₀为9.1μg.mL ^-1，比商品试剂比美噻唑（54.9μg.mL ^-1）更好。另外，通过扫描电子显微镜（SEM）研究了目标化合物E ₁₅对Xac的可能的抗菌机理。