A stepwise approach to the pharmacological treatment of asthma is a key feature of current asthma guidelines [1–4]. Through algorithms, treatment intensity is “stepped up” to obtain asthma control and reduce the risk of exacerbations, and “stepped down” after a period of prolonged control and absence of exacerbations. Traditional algorithms advocated short-acting β2-agonist (SABA) reliever therapy for all levels of severity, initially as sole therapy at Step 1, together with maintenance “low dose” inhaled corticosteroids (ICS) at Step 2, with maintenance ICS/long-acting β2-agonist (LABA) at “low”, “moderate” or “high” doses at Steps 3 and 4, and finally with “add-on” therapies at Step 5. A practical “anti-inflammatory reliever therapy”-based algorithm based on the GINA 2019 update is presented, together with a prototype action plan to facilitate its implementation. http://bit.ly/33C2s5u

中文翻译：

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ICS-福莫特罗缓解治疗成人哮喘的逐步治疗算法

哮喘药物治疗的逐步方法是当前哮喘指南的一个关键特征 [1-4]。通过算法，治疗强度被“提高”以获得哮喘控制并降低急性发作的风险，并在长时间控制且没有恶化后“降低”治疗强度。传统算法提倡针对所有严重程度的短效β2受体激动剂（SABA）缓解治疗，最初作为步骤1的单独治疗，同时在步骤2维持“低剂量”吸入皮质类固醇（ICS），维持ICS/长效在第 3 步和第 4 步以“低”、“中”或“高”剂量使用作用 β2-激动剂 (LABA)，最后在第 5 步使用“附加”疗法。 基于实用的“抗炎缓解疗法”提出了基于 GINA 2019 更新的算法，连同原型行动计划，以促进其实施。http://bit.ly/33C2s5u