Wine pomace by-products are an important source of phenolic acids with significant health benefits. However, phenolic acid bioavailability in vivo has been little studied and there are few comparative studies on bioavailability between red and white wine pomace and the effect of intake of different doses. The qualitative and quantitative profile of phenolic acid metabolites in plasma and urine samples from Wistar rats was obtained by gas chromatography/mass detection, after oral administration of four doses (50, 100, 150, and 300 mg) of both the red and the white wine pomace products (rWPP and wWPP, respectively). The antioxidant capacity of the plasma samples assessed by both the ABTS and the FRAP levels was also evaluated. The results showed that neither the bioavailability nor the antioxidant capacity in vivo of the rWPP increased at high doses. However, both parameters were dependent on the intake of the wWPP.

中文翻译：

---

Wistar大鼠摄入白和红葡萄酒果渣产品后对多酚生物利用度的剂量反应。

葡萄酒渣渣副产物是酚酸的重要来源，对健康有重大益处。然而，关于酚酸在体内的生物利用度的研究很少，关于红葡萄酒和白葡萄酒果渣之间的生物利用度以及不同剂量摄入的影响的比较研究也很少。Wistar大鼠血浆和尿液样品中酚酸代谢物的定性和定量特征是通过口服和口服四种剂量（50、100、150和300 mg）红色和白色的气相色谱/质谱检测获得的葡萄酒果渣产品（分别为rWPP和wWPP）。还评估了通过ABTS和FRAP水平评估的血浆样品的抗氧化能力。结果表明，高剂量rWPP的体内生物利用度和抗氧化能力均未增加。