To examine the association between urinary metabolites of polycyclic aromatic hydrocarbons (OH-PAHs) and diabetes, online databases, including PubMed, Scopus, and Web of Science, were searched on July 17, 2019. Of the 668 articles identified through searching, six cross-sectional studies involving 24,406 participants were included. The pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using a random-effect model. Heterogeneity was measured by reporting the I-square index. Moreover, subgroup analysis according to types of metabolites was performed. We found a significantly higher odds of diabetes in the highest versus the lowest category of urinary naphthalene (NAP), fluorine (FLU), phenanthrene (PHEN), and total OH-PAH metabolites. The pooled OR (95% CI) was estimated at 1.47 (1.17, 1.78), 1.50 (1.29, 1.71), 1.41 (1.21, 1.60), and 1.61 (1.01, 2.21), respectively. We also found a significant association per 1-fold increase in FLU (OR = 1.09, 95% CI [1.00, 1.19]) and PHEN (OR = 1.19, 95% CI [1.08, 1.30]) metabolites. In subgroup analysis stratified by types of OH-PAH metabolites, A significant stronger odds of diabetes was observed in the highest versus the lowest category of 2-PHEN (OR = 1.66, 95% CI [1.32, 2.00]), 2-NAP (OR = 1.66, 95% CI [1.16, 2.17]), 2-FLU (OR = 1.62, 95% CI [1.28, 1.97]), and 9-FLU (OR = 1.62, 95% CI [1.21, 2.04]) metabolites. Furthermore, there was a meaningfully greater likelihood of diabetes per 1-fold increase in 2-FLU (OR = 1.34, 95% CI [1.10, 1.57]), 2-PHEN (OR = 1.33, 95% CI [1.14, 1.51]), and 3-PHEN (OR = 1.19, 95% CI [1.04, 1.34]) metabolites. In conclusion, our study suggests the significant odds of association between urinary OH-PAH metabolites and diabetes.

中文翻译：

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多环芳烃尿代谢产物与糖尿病的关系：系统评价和荟萃分析研究。

为了检查多环芳烃（OH-PAHs）的尿代谢产物与糖尿病之间的关联，于2019年7月17日搜索了在线数据库，包括PubMed，Scopus和Web of Science。通过搜索发现的668篇文章中，有6篇交叉包括24,406名参与者的横断面研究。使用随机效应模型计算合并的优势比（OR）和95％置信区间（CI）。异质性是通过报告I平方指数来衡量的。此外，根据代谢物类型进行了亚组分析。我们发现，尿萘（NAP），氟（FLU），菲（PHEN）和总OH-PAH代谢物的最高类别与最低类别相比，糖尿病的几率明显更高。合并OR（95％CI）估计为1.47（1.17，1.78），1.50（1.29，1.71），1.41（1.21，1.60），和1.61（1.01，2.21）。我们还发现，FLU（OR = 1.09，95％CI [1.00，1.19]）和PHEN（OR = 1.19，95％CI [1.08，1.30]）代谢物每增加1倍，显着相关。在按OH-PAH代谢物类型分层的亚组分析中，在2-PHEN的最高类别与最低类别（OR = 1.66，95％CI [1.32，2.00]），2-NAP中观察到明显更高的糖尿病几率。 OR = 1.66，95％CI [1.16，2.17]），2-FLU（OR = 1.62，95％CI [1.28，1.97]）和9-FLU（OR = 1.62，95％CI [1.21，2.04]）代谢产物。此外，2-FLU（OR = 1.34，95％CI [1.10，1.57]），2-PHEN（OR = 1.33，95％CI [1.14，1.51]每增加1倍，糖尿病的可能性就显着增加。 ）和3-PHEN（OR = 1.19，95％CI [1.04，1.34]）代谢产物。结论，