Diabetic nephropathy (DN) is a complication of diabetes mellitus that is characterized by the gradual loss of kidney function, which results in increased levels of albumin in the urine. The Pro12Ala polymorphism in the peroxisome proliferator‐activated receptor‐γ2 gene has been confirmed to improve insulin sensitivity, but its association with susceptibility to DN in patients with type 2 diabetes remains inconclusive.

中文翻译：

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Pro12Ala 多态性与 2 型糖尿病肾病蛋白尿的相关性。

糖尿病肾病 (DN) 是糖尿病的一种并发症，其特征是肾功能逐渐丧失，导致尿液中白蛋白水平升高。过氧化物酶体增殖物激活受体-γ2 基因中的 Pro12Ala 多态性已被证实可改善胰岛素敏感性，但其与 2 型糖尿病患者对 DN 易感性​​的关联仍无定论。