Humoral immunity is an essential component of the protective immune response to flavivirus infection. Typically, primary infection generates a robust neutralizing antibody response that mediates viral control and protection. It is becoming increasingly apparent that secondary infection with a closely related flavivirus strain can result in immunological cross-reactivity; however, the consequences to infection outcome remain controversial. Since its introduction to Brazil in 2015, Zika virus (ZIKV) has caused an epidemic of fetal congenital malformations within the Americas. Because ZIKV is a mosquito-borne flavivirus with a high degree of sequence and structural homology to Dengue virus (DENV), the role of immunological cross-reactivity in ZIKV and DENV infections has become a great concern. In this review, we highlight contemporary findings that implicate a role for flavivirus antibodies in mediating protection, contributing to pathogenesis, and seeding the human placenta.

中文翻译：

---

寨卡病毒感染期间的交叉反应抗体：保护，发病机制和胎盘植入。

体液免疫是对黄病毒感染的保护性免疫反应的重要组成部分。通常，原发感染会产生强大的中和抗体反应，介导病毒的控制和保护作用。越来越明显的是，密切相关的黄病毒株继发感染可导致免疫学交叉反应。然而，对感染结果的影响仍存在争议。自2015年将其引入巴西以来，寨卡病毒（ZIKV）引起了美洲地区胎儿先天性畸形的流行。由于ZIKV是一种蚊子传播的黄病毒，与登革热病毒（DENV）具有高度的序列和结构同源性，因此免疫交叉反应在ZIKV和DENV感染中的作用已引起广泛关注。在这篇评论中